Cytotec and Aseptic necrosis - a phase IV clinical study of FDA data

Summary:

Aseptic necrosis is reported as a side effect among people who take Cytotec (misoprostol), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Fosamax, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Aseptic necrosis when taking Cytotec. It is created by eHealthMe based on reports of 5,765 people who have side effects when taking Cytotec from the FDA, and is updated regularly.

What is Cytotec?

Cytotec has active ingredients of misoprostol. It is often used in abortion. eHealthMe is studying from 5,812 Cytotec users. Check the latest studies of Cytotec.

What is Aseptic necrosis?

Aseptic necrosis (the death of bone tissue due to a lack of blood supply) is found to be associated with 1,347 drugs and 1,696 conditions by eHealthMe. Check the latest studies of Aseptic necrosis.

On Aug, 05, 2026

5,765 people reported to have side effects when taking Cytotec.
Among them, 39 people (0.68%) have Aseptic necrosis.

Among these 39 people:

How long have people been on Cytotec when they have Aseptic necrosis? *

What is the gender of people who have Aseptic necrosis when taking Cytotec? *

female: 38.46 %
male: 61.54 %

What is the age of people who have Aseptic necrosis when taking Cytotec? *

What are other drugs people take besides Cytotec? *

What are other side effects people have besides Aseptic necrosis? *

Joint Pain: 12 people, 30.77%
Depression: 11 people, 28.21%
Osteomyelitis (infection of bone): 9 people, 23.08%
Stress And Anxiety: 8 people, 20.51%
Weight Decreased: 8 people, 20.51%
Haematochezia (passage of stools containing blood): 8 people, 20.51%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 20.51%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 7 people, 17.95%
Hyperthyroidism (over activity of the thyroid gland): 7 people, 17.95%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 17.95%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 15 people, 38.46%
Osteoporosis (bones weak and more likely to break): 12 people, 30.77%
High Blood Pressure: 8 people, 20.51%
High Blood Cholesterol: 7 people, 17.95%
Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 6 people, 15.38%
Hiv Infection: 4 people, 10.26%
Metastases To Bone (cancer spreads to bone): 4 people, 10.26%
Breast Cancer: 3 people, 7.69%
Pneumonia: 2 people, 5.13%
Gastric Mucosal Lesion (lesion of stomach mucous membrane): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Cytotec and have Aseptic necrosis?

- Check whether Aseptic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cytotec:

Cytotec (5,812 reports)

Aseptic necrosis treatments and more:

Aseptic necrosis (59,829 reports)

Browse all side effects of Cytotec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aseptic necrosis:

Aseptic necrosis (1,347 drugs)

Browse all the conditions that are associated with Aseptic necrosis:

Aseptic necrosis (1,696 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on misoprostol (the active ingredients of Cytotec) and Cytotec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.