Cytoxan and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Cytoxan (cyclophosphamide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Zometa, and have Pain.

The phase IV clinical study analyzes which people have Mental status changes when taking Cytoxan. It is created by eHealthMe based on reports of 19,522 people who have side effects when taking Cytoxan from the FDA, and is updated regularly.

What is Cytoxan?

Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,496 drugs and 1,760 conditions by eHealthMe. Check the latest studies of Mental status changes.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

19,522 people reported to have side effects when taking Cytoxan.
Among them, 131 people (0.67%) have Mental status changes.

Could Cytoxan cause Mental status changes?

Among these 131 people:

How long have people been on Cytoxan when they have Mental status changes? *

Click here to view more results

What is the gender of people who have Mental status changes when taking Cytoxan? *

Click here to view

* Approximation only. Some reports may have incomplete information.

Do you take Cytoxan and have Mental status changes?

- Check whether Mental status changes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cytoxan:

Cytoxan (19,693 reports)

Mental status changes treatments and more:

Mental status changes (32,338 reports)

How severe was Mental status changes and when was it recovered:

Mental status changes in Cytoxan

Expand to all the drugs that have ingredients of cyclophosphamide:

Mental status changes and drugs with ingredients of cyclophosphamide (612 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cytoxan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,496 drugs)

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,760 conditions)

Related publications that referenced our studies

Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on cyclophosphamide (the active ingredients of Cytoxan) and Cytoxan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.