Cytoxan and Paraplegia - a phase IV clinical study of FDA data

Summary:

Paraplegia is reported as a side effect among people who take Cytoxan (cyclophosphamide), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Gabapentin, and have Deep venous thrombosis.

The phase IV clinical study analyzes which people have Paraplegia when taking Cytoxan. It is created by eHealthMe based on reports of 19,522 people who have side effects when taking Cytoxan from the FDA, and is updated regularly.

What is Cytoxan?

Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.

What is Paraplegia?

Paraplegia (paralysis of the legs and lower body) is found to be associated with 435 drugs and 537 conditions by eHealthMe. Check the latest studies of Paraplegia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

19,522 people reported to have side effects when taking Cytoxan.
Among them, 24 people (0.12%) have Paraplegia.

Among these 24 people:

How long have people been on Cytoxan when they have Paraplegia? *

What is the gender of people who have Paraplegia when taking Cytoxan? *

female: 50 %
male: 50 %

What is the age of people who have Paraplegia when taking Cytoxan? *

What are other drugs people take besides Cytoxan? *

What are other side effects people have besides Paraplegia? *

Urinary Incontinence (inability to control the flow of urine and involuntary urination): 24 people, 100.00%
Faecal Incontinence (a lack of control over passing stool): 24 people, 100.00%
Insomnia (sleeplessness): 23 people, 95.83%
Pain: 23 people, 95.83%
Spinal Osteoarthritis (joint cartilage loss in spine): 22 people, 91.67%
Weakness: 21 people, 87.50%
Compression Fracture (fracture due to pressure caused by injury): 21 people, 87.50%
Fatigue (feeling of tiredness): 20 people, 83.33%
Stress And Anxiety: 19 people, 79.17%
Dyspnea (difficult or laboured breathing): 19 people, 79.17%

What are the existing conditions these people have? *

Stress And Anxiety: 14 people, 58.33%
Pain: 14 people, 58.33%
Metastases To Bone (cancer spreads to bone): 14 people, 58.33%
High Blood Pressure: 14 people, 58.33%
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 14 people, 58.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 58.33%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 14 people, 58.33%
Insomnia (sleeplessness): 9 people, 37.50%
Neoplasm Malignant (cancer tumour): 2 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Cytoxan and have Paraplegia?

- Check whether Paraplegia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cytoxan:

Cytoxan (19,693 reports)

Paraplegia treatments and more:

Paraplegia (3,983 reports)

Browse all side effects of Cytoxan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Paraplegia:

Paraplegia (435 drugs)

Browse all the conditions that are associated with Paraplegia:

Paraplegia (537 conditions)

Related publications that referenced our studies

Lee, Y. J., & Park, K. , "Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension", Drug safety-case reports, 2018 Jan .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
Lee, Y. J., & Park, K. , "Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension", Drug safety-case reports, 2018 Jan .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on cyclophosphamide (the active ingredients of Cytoxan) and Cytoxan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.