Darvocet and Aggression - a phase IV clinical study of FDA data

Summary:

Aggression is reported as a side effect among people who take Darvocet (acetaminophen; propoxyphene hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for 10+ years also take Chantix, and have Quit smoking.

The phase IV clinical study analyzes which people have Aggression when taking Darvocet. It is created by eHealthMe based on reports of 11,339 people who have side effects when taking Darvocet from the FDA, and is updated regularly.

What is Darvocet?

Darvocet has active ingredients of acetaminophen; propoxyphene hydrochloride. It is often used in pain. eHealthMe is studying from 12,131 Darvocet users. Check the latest studies of Darvocet.

What is Aggression?

Aggression is found to be associated with 1,526 drugs and 1,965 conditions by eHealthMe. Check the latest studies of Aggression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

11,339 people reported to have side effects when taking Darvocet.
Among them, 35 people (0.31%) have Aggression.

Among these 35 people:

How long have people been on Darvocet when they have Aggression? *

What is the gender of people who have Aggression when taking Darvocet? *

female: 68.57 %
male: 31.43 %

What is the age of people who have Aggression when taking Darvocet? *

What are other drugs people take besides Darvocet? *

Chantix: 14 people, 40.00%
Oxycontin: 9 people, 25.71%
Neurontin: 9 people, 25.71%
Vicodin: 7 people, 20.00%
Ms Contin: 7 people, 20.00%
Prevacid: 5 people, 14.29%
Hydrocodone Bitartrate And Acetaminophen: 5 people, 14.29%
Lortab: 5 people, 14.29%
Lisinopril: 4 people, 11.43%
Levaquin: 4 people, 11.43%

What are other side effects people have besides Aggression? *

Depression: 15 people, 42.86%
Stress And Anxiety: 11 people, 31.43%
Agitation (state of anxiety or nervous excitement): 8 people, 22.86%
Constipation: 7 people, 20.00%
Memory Loss: 7 people, 20.00%
Suicide Attempt: 7 people, 20.00%
Suicidal Ideation: 6 people, 17.14%
Mood Swings (an extreme or rapid change in mood): 6 people, 17.14%
Drug Dependence: 5 people, 14.29%
Insomnia (sleeplessness): 5 people, 14.29%

What are the existing conditions these people have? *

Quit Smoking: 13 people, 37.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.29%
High Blood Pressure: 3 people, 8.57%
Stress And Anxiety: 3 people, 8.57%
Bipolar Disorder (mood disorder): 3 people, 8.57%
Hypersensitivity: 3 people, 8.57%
Migraine (headache): 2 people, 5.71%
Asthma: 2 people, 5.71%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 5.71%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

Do you take Darvocet and have Aggression?

- Check whether Aggression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Darvocet:

Darvocet (12,131 reports)

Aggression treatments and more:

Aggression (65,312 reports)

How severe was Aggression and when was it recovered:

Aggression in Darvocet

Expand to all the drugs that have ingredients of acetaminophen; propoxyphene hydrochloride:

Aggression and drugs with ingredients of acetaminophen; propoxyphene hydrochloride (40 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Darvocet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aggression:

Aggression (1,526 drugs)

Browse all the conditions that are associated with Aggression:

Aggression (1,965 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; propoxyphene hydrochloride (the active ingredients of Darvocet) and Darvocet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.