Decadron and Megacolon - a phase IV clinical study of FDA data

Summary:

Megacolon is reported as a side effect among people who take Decadron (dexamethasone), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Neurontin, and have Diverticulitis.

The phase IV clinical study analyzes which people have Megacolon when taking Decadron. It is created by eHealthMe based on reports of 46,837 people who have side effects when taking Decadron from the FDA, and is updated regularly.

What is Decadron?

Decadron has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 47,210 Decadron users. Check the latest studies of Decadron.

What is Megacolon?

Megacolon (a very dilated colon) is found to be associated with 239 drugs and 402 conditions by eHealthMe. Check the latest studies of Megacolon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

46,837 people reported to have side effects when taking Decadron.
Among them, 15 people (0.03%) have Megacolon.

Among these 15 people:

How long have people been on Decadron when they have Megacolon? *

What is the gender of people who have Megacolon when taking Decadron? *

female: 20 %
male: 80 %

What is the age of people who have Megacolon when taking Decadron? *

What are other drugs people take besides Decadron? *

What are other side effects people have besides Megacolon? *

Cardiac Failure Congestive: 12 people, 80.00%
High Blood Pressure: 11 people, 73.33%
Pleural Effusion (water on the lungs): 11 people, 73.33%
Heart Attack: 10 people, 66.67%
Dyspnea (difficult or laboured breathing): 10 people, 66.67%
Emotional Distress: 10 people, 66.67%
Faecal Incontinence (a lack of control over passing stool): 10 people, 66.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 66.67%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 10 people, 66.67%
Discomfort: 10 people, 66.67%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 1 person, 6.67%
Iron Deficiency: 1 person, 6.67%
Insomnia (sleeplessness): 1 person, 6.67%
Herpes Zoster: 1 person, 6.67%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Decadron and have Megacolon?

- Check whether Megacolon is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Decadron:

Decadron (47,210 reports)

Megacolon treatments and more:

Megacolon (1,914 reports)

Browse all side effects of Decadron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Megacolon:

Megacolon (240 drugs)

Browse all the conditions that are associated with Megacolon:

Megacolon (402 conditions)

Related publications that referenced our studies

Bartlett R, Hartle AJ, "Routine use of dexamethasone for postoperative nausea and vomiting: the case against", Anaesthesia, 2013 Sep .
Bartlett R, Hartle AJ, "Routine use of dexamethasone for postoperative nausea and vomiting: the case against", Anaesthesia, 2013 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on dexamethasone (the active ingredients of Decadron) and Decadron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.