Depakote and Tibia fracture - a phase IV clinical study of FDA data

Summary:

Tibia fracture is reported as a side effect among people who take Depakote (divalproex sodium), especially for people who are male, 40-49 old, have been taking the drug for 6 - 12 months also take Tylenol, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Tibia fracture when taking Depakote. It is created by eHealthMe based on reports of 52,619 people who have side effects when taking Depakote from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Tibia fracture?

Tibia fracture (fracture of lower leg bone) is found to be associated with 645 drugs and 670 conditions by eHealthMe. Check the latest studies of Tibia fracture.

On Jul, 30, 2026

52,619 people reported to have side effects when taking Depakote.
Among them, 19 people (0.04%) have Tibia fracture.

$Could Depakote cause Tibia fracture?$

Among these 19 people:

How long have people been on Depakote when they have Tibia fracture? *

What is the gender of people who have Tibia fracture when taking Depakote? *

female: 22.22 %
male: 77.78 %

What is the age of people who have Tibia fracture when taking Depakote? *

What are other drugs people take besides Depakote? *

What are other side effects people have besides Tibia fracture? *

Fall: 5 people, 26.32%
Fibula Fracture: 4 people, 21.05%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 21.05%
Dizziness: 4 people, 21.05%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 15.79%
High Blood Cholesterol: 3 people, 15.79%
Lower Limb Fracture: 3 people, 15.79%
Confusional State: 3 people, 15.79%
Nausea And Vomiting: 3 people, 15.79%
Weight Increased: 3 people, 15.79%

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 15.79%
Depression: 3 people, 15.79%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 15.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.53%
Pain: 2 people, 10.53%
Nausea And Vomiting: 2 people, 10.53%
Nausea (feeling of having an urge to vomit): 2 people, 10.53%
Headache (pain in head): 2 people, 10.53%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 5.26%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Tibia fracture?

- Check whether Tibia fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote:

Depakote (55,581 reports)

Tibia fracture treatments and more:

Tibia fracture (6,376 reports)

Browse all side effects of Depakote:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tibia fracture:

Tibia fracture (645 drugs)

Browse all the conditions that are associated with Tibia fracture:

Tibia fracture (670 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.