1. Home
  2. Analysis
  3. Ultram
  4. Bladder-cancer

Ultram and Bladder cancer - a phase IV clinical study of FDA data

Summary:

Bladder cancer is reported as a side effect among people who take Ultram (tramadol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Neurontin, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Bladder cancer when taking Ultram. It is created by eHealthMe based on reports of 26,802 people who have side effects when taking Ultram from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Bladder cancer?

Bladder cancer is found to be associated with 725 drugs and 1,028 conditions by eHealthMe. Check the latest studies of Bladder cancer.

On Jul, 30, 2026

26,802 people reported to have side effects when taking Ultram.
Among them, 13 people (0.05%) have Bladder cancer.

Could Ultram cause Bladder cancer?

Among these 13 people:

How long have people been on Ultram when they have Bladder cancer? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 50 %

What is the gender of people who have Bladder cancer when taking Ultram? *

  • female: 54.55 %
  • male: 45.45 %

What is the age of people who have Bladder cancer when taking Ultram? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 10 %
  • 50-59: 30 %
  • 60+: 60 %

What are other drugs people take besides Ultram? *

  1. Neurontin: 5 people, 38.46%
  2. Actos: 3 people, 23.08%
  3. Aleve: 3 people, 23.08%
  4. Lipitor: 3 people, 23.08%
  5. Cefadroxil: 2 people, 15.38%
  6. Jakafi: 2 people, 15.38%
  7. Vioxx: 2 people, 15.38%
  8. Dexilant: 2 people, 15.38%
  9. Lasix: 2 people, 15.38%
  10. Lexapro: 2 people, 15.38%

What are other side effects people have besides Bladder cancer? *

  1. Increased Tendency To Bruise (increased tendency to injure the underlying soft tissue or bone): 3 people, 23.08%
  2. Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 2 people, 15.38%
  3. Metastases To Liver (cancer spreads to liver): 2 people, 15.38%
  4. Marrow Hyperplasia (increased bone marrow): 2 people, 15.38%
  5. Malaise (a feeling of general discomfort or uneasiness): 2 people, 15.38%
  6. Light Chain Disease (a rare blood cell disease which is characterized by deposition of fragments of infection-fighting immunoglobulins): 2 people, 15.38%
  7. Injection Site Stinging: 2 people, 15.38%
  8. Immunoglobulins Decreased: 2 people, 15.38%
  9. Viral Infection: 2 people, 15.38%
  10. Hot Flush (sudden feelings of heat): 2 people, 15.38%

What are the existing conditions these people have? *

  1. Type 2 Diabetes: 3 people, 23.08%
  2. Sinusitis (inflammation of sinus): 2 people, 15.38%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 15.38%
  4. Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 15.38%
  5. Osteoporosis (bones weak and more likely to break): 2 people, 15.38%
  6. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 15.38%
  7. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 7.69%
  8. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 1 person, 7.69%
  9. Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 7.69%
  10. Arthropathy: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and have Bladder cancer?

- Check whether Bladder cancer is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ultram:

Bladder cancer treatments and more:

How severe was Bladder cancer and when was it recovered:

Expand to all the drugs that have ingredients of tramadol hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ultram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bladder cancer:

Browse all the conditions that are associated with Bladder cancer:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Ultram) and Ultram (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.