Depo-testosterone and Injection site mass - a phase IV clinical study of FDA data

Summary:

Injection site mass is reported as a side effect among people who take Depo-testosterone (testosterone cypionate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Digoxin, and have Blood testosterone decreased.

The phase IV clinical study analyzes which people have Injection site mass when taking Depo-testosterone. It is created by eHealthMe based on reports of 4,183 people who have side effects when taking Depo-testosterone from the FDA, and is updated regularly.

What is Depo-testosterone?

Depo-testosterone has active ingredients of testosterone cypionate. It is often used in low testosterone. eHealthMe is studying from 4,295 Depo-testosterone users. Check the latest studies of Depo-testosterone.

What is Injection site mass?

Injection site mass is found to be associated with 832 drugs and 787 conditions by eHealthMe. Check the latest studies of Injection site mass.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

4,183 people reported to have side effects when taking Depo-testosterone.
Among them, 14 people (0.33%) have Injection site mass.

Could Depo-testosterone cause Injection site mass?

Among these 14 people:

How long have people been on Depo-testosterone when they have Injection site mass? *

What is the gender of people who have Injection site mass when taking Depo-testosterone? *

female: 0.0 %
male: 100 %

What is the age of people who have Injection site mass when taking Depo-testosterone? *

What are other drugs people take besides Depo-testosterone? *

What are other side effects people have besides Injection site mass? *

Injection Site Pain: 8 people, 57.14%
Injection Site Erythema (redness at injection site): 2 people, 14.29%
Blood Testosterone Increased: 2 people, 14.29%
Fatigue (feeling of tiredness): 2 people, 14.29%
Insomnia (sleeplessness): 2 people, 14.29%
Injection Site Swelling: 2 people, 14.29%
Peripheral Swelling: 1 person, 7.14%
Dysstasia (difficulty in standing): 1 person, 7.14%
Fever: 1 person, 7.14%
Gait Disturbance: 1 person, 7.14%

What are the existing conditions these people have? *

Blood Testosterone Decreased: 7 people, 50.00%
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 3 people, 21.43%
Pain: 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Thyroid Diseases: 1 person, 7.14%
Sleep Disorder: 1 person, 7.14%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 7.14%
Pituitary Tumor: 1 person, 7.14%
Essential Tremor: 1 person, 7.14%
Erection Problems: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Depo-testosterone and have Injection site mass?

- Check whether Injection site mass is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depo-testosterone:

Depo-testosterone (4,295 reports)

Browse all side effects of Depo-testosterone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site mass:

Injection site mass (832 drugs)

Browse all the conditions that are associated with Injection site mass:

Injection site mass (787 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on testosterone cypionate (the active ingredients of Depo-testosterone) and Depo-testosterone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.