Diclofenac sodium and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Diclofenac sodium (diclofenac sodium), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Cimzia, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Diclofenac sodium. It is created by eHealthMe based on reports of 41,731 people who have side effects when taking Diclofenac sodium from the FDA, and is updated regularly.

What is Diclofenac sodium?

Diclofenac sodium has active ingredients of diclofenac sodium. It is often used in arthritis. eHealthMe is studying from 43,017 Diclofenac sodium users. Check the latest studies of Diclofenac sodium.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 962 drugs and 1,224 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Apr, 21, 2026

41,731 people reported to have side effects when taking Diclofenac sodium.
Among them, 1,457 people (3.49%) have Knee joint replacement.

Could Diclofenac sodium cause Knee joint replacement?

Among these 1,457 people:

How long have people been on Diclofenac sodium when they have Knee joint replacement? *

Click here to view more results

What is the gender of people who have Knee joint replacement when taking Diclofenac sodium? *

Click here to view

What is the age of people who have Knee joint replacement when taking Diclofenac sodium? *

Click here to view more results

* Approximation only. Some reports may have incomplete information.

Do you take Diclofenac sodium and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diclofenac sodium:

Diclofenac sodium (43,017 reports)

Knee joint replacement treatments and more:

Knee joint replacement (26,754 reports)

How severe was Knee joint replacement and when was it recovered:

Knee joint replacement in Diclofenac sodium

Expand to all the drugs that have ingredients of diclofenac sodium:

Knee joint replacement and drugs with ingredients of diclofenac sodium (1,646 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diclofenac sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (962 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,224 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac sodium (the active ingredients of Diclofenac sodium) and Diclofenac sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.