Didronel and Osteoarthritis - a phase IV clinical study of FDA data

Summary:

Osteoarthritis is reported as a side effect among people who take Didronel (etidronate disodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Fosamax, and have Osteoporosis.

The phase IV clinical study analyzes which people have Osteoarthritis when taking Didronel. It is created by eHealthMe based on reports of 1,586 people who have side effects when taking Didronel from the FDA, and is updated regularly.

What is Didronel?

Didronel has active ingredients of etidronate disodium. eHealthMe is studying from 1,587 Didronel users. Check the latest studies of Didronel.

What is Osteoarthritis?

Osteoarthritis (a joint disease caused by cartilage loss in a joint) is found to be associated with 1,879 drugs and 2,647 conditions by eHealthMe. Check the latest studies of Osteoarthritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 27, 2026

1,586 people reported to have side effects when taking Didronel.
Among them, 29 people (1.83%) have Osteoarthritis.

Among these 29 people:

How long have people been on Didronel when they have Osteoarthritis? *

What is the gender of people who have Osteoarthritis when taking Didronel? *

female: 86.96 %
male: 13.04 %

What is the age of people who have Osteoarthritis when taking Didronel? *

What are other drugs people take besides Didronel? *

Fosamax: 25 people, 86.21%
Prednisone: 14 people, 48.28%
Plaquenil: 11 people, 37.93%
Alendronate Sodium: 10 people, 34.48%
Boniva: 8 people, 27.59%
Premarin: 7 people, 24.14%
Daypro: 4 people, 13.79%
Hydroxychloroquine Sulfate: 4 people, 13.79%
Actonel: 3 people, 10.34%
Prilosec: 3 people, 10.34%

What are other side effects people have besides Osteoarthritis? *

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 26 people, 89.66%
Osteopenia (a condition where bone mineral density is lower than normal): 16 people, 55.17%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 7 people, 24.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 24.14%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 4 people, 13.79%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.90%
Gastric Ulcer (stomach ulcer): 2 people, 6.90%
Asthma: 2 people, 6.90%
Pain: 1 person, 3.45%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Didronel and have Osteoarthritis?

- Check whether Osteoarthritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Didronel:

Didronel (1,587 reports)

Osteoarthritis treatments and more:

Osteoarthritis (95,655 reports)

Browse all side effects of Didronel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoarthritis:

Osteoarthritis (1,879 drugs)

Browse all the conditions that are associated with Osteoarthritis:

Osteoarthritis (2,647 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on etidronate disodium (the active ingredients of Didronel) and Didronel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.