Differin and Weight increased - a phase IV clinical study of FDA data

Summary:

Weight increased is reported as a side effect among people who take Differin (adapalene), especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months also take Wellbutrin, and have Birth control.

The phase IV clinical study analyzes which people have Weight increased when taking Differin. It is created by eHealthMe based on reports of 5,708 people who have side effects when taking Differin from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Weight increased?

Weight increased is found to be associated with 2,885 drugs and 3,947 conditions by eHealthMe. Check the latest studies of Weight increased.

On Apr, 10, 2026

5,708 people reported to have side effects when taking Differin.
Among them, 21 people (0.37%) have Weight increased.

Among these 21 people:

How long have people been on Differin when they have Weight increased? *

What is the gender of people who have Weight increased when taking Differin? *

female: 95.24 %
male: 4.76 %

What is the age of people who have Weight increased when taking Differin? *

What are other drugs people take besides Differin? *

What are other side effects people have besides Weight increased? *

Nausea (feeling of having an urge to vomit): 9 people, 42.86%
Mood Swings (an extreme or rapid change in mood): 7 people, 33.33%
Sinusitis (inflammation of sinus): 6 people, 28.57%
Suicidal Ideation: 6 people, 28.57%
Intracranial Venous Sinus Thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain): 6 people, 28.57%
Biliary Dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi): 6 people, 28.57%
Muscle Aches (muscle pain): 6 people, 28.57%
Anger: 6 people, 28.57%
Dizziness: 6 people, 28.57%
High Blood Pressure: 6 people, 28.57%

What are the existing conditions these people have? *

Birth Control: 6 people, 28.57%
Migraine (headache): 5 people, 23.81%
Headache (pain in head): 5 people, 23.81%
Depression: 5 people, 23.81%
Pain: 3 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.52%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 9.52%
Rosacea (a skin condition that causes facial redness): 1 person, 4.76%
Irritable Bowel Syndrome: 1 person, 4.76%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and have Weight increased?

- Check whether Weight increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Differin:

Differin (5,740 reports)

Weight increased treatments and more:

Weight increased (279,367 reports)

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight increased:

Weight increased (2,885 drugs)

Browse all the conditions that are associated with Weight increased:

Weight increased (3,947 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.