Diflucan and Diverticular perforation - a phase IV clinical study of FDA data

Summary:

Diverticular perforation is reported as a side effect among people who take Diflucan (fluconazole), especially for people who are male, 60+ old, also take Levaquin, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Diverticular perforation when taking Diflucan. It is created by eHealthMe based on reports of 27,552 people who have side effects when taking Diflucan from the FDA, and is updated regularly.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

What is Diverticular perforation?

Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated) is found to be associated with 365 drugs and 413 conditions by eHealthMe. Check the latest studies of Diverticular perforation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

27,552 people reported to have side effects when taking Diflucan.
Among them, 14 people (0.05%) have Diverticular perforation.

Could Diflucan cause Diverticular perforation?

Among these 14 people:

What is the gender of people who have Diverticular perforation when taking Diflucan? *

female: 50 %
male: 50 %

What is the age of people who have Diverticular perforation when taking Diflucan? *

What are other drugs people take besides Diflucan? *

What are other side effects people have besides Diverticular perforation? *

White Blood Cell Count Decreased: 4 people, 28.57%
Abdominal Abscess (collection of pus in abdomen): 3 people, 21.43%
Aspartate Aminotransferase Increased: 3 people, 21.43%
Haemoglobin Decreased: 3 people, 21.43%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 3 people, 21.43%
Thrombocytopenia (decrease of platelets in blood): 3 people, 21.43%
Alanine Aminotransferase Increased: 3 people, 21.43%
Abscess (pus): 3 people, 21.43%
Anaemia (lack of blood): 2 people, 14.29%
Blood Albumin Decreased: 2 people, 14.29%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 42.86%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 21.43%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 2 people, 14.29%
Constipation: 2 people, 14.29%
Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 14.29%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 14.29%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 1 person, 7.14%
Oral Cancer (mouth cancer): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Diflucan and have Diverticular perforation?

- Check whether Diverticular perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diflucan:

Diflucan (28,471 reports)

Browse all side effects of Diflucan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diverticular perforation:

Diverticular perforation (365 drugs)

Browse all the conditions that are associated with Diverticular perforation:

Diverticular perforation (413 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluconazole (the active ingredients of Diflucan) and Diflucan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.