Diphen and Enterococcal infection - a phase IV clinical study of FDA data

Summary:

Enterococcal infection is reported as a side effect among people who take Diphen (diphenhydramine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Acetaminophen, and have Acute myeloid leukaemia.

The phase IV clinical study analyzes which people have Enterococcal infection when taking Diphen. It is created by eHealthMe based on reports of 113,958 people who have side effects when taking Diphen from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Enterococcal infection?

Enterococcal infection is found to be associated with 624 drugs and 760 conditions by eHealthMe. Check the latest studies of Enterococcal infection.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

113,958 people reported to have side effects when taking Diphen.
Among them, 56 people (0.05%) have Enterococcal infection.

Could Diphen cause Enterococcal infection?

Among these 56 people:

How long have people been on Diphen when they have Enterococcal infection? *

What is the gender of people who have Enterococcal infection when taking Diphen? *

female: 35.19 %
male: 64.81 %

What is the age of people who have Enterococcal infection when taking Diphen? *

What are other drugs people take besides Diphen? *

What are other side effects people have besides Enterococcal infection? *

Fever: 18 people, 32.14%
Nausea (feeling of having an urge to vomit): 17 people, 30.36%
Febrile Neutropenia (fever with reduced white blood cells): 17 people, 30.36%
Staphylococcal Infection (an infection with staphylococcus bacteria): 15 people, 26.79%
Pneumonia: 14 people, 25.00%
Hypotension (abnormally low blood pressure): 12 people, 21.43%
Pleural Effusion (water on the lungs): 11 people, 19.64%
Thrombocytopenia (decrease of platelets in blood): 11 people, 19.64%
Hypokalemia (low potassium): 10 people, 17.86%
Nausea And Vomiting: 10 people, 17.86%

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 20 people, 35.71%
High Blood Pressure: 4 people, 7.14%
Vasculitis (inflammation of a blood vessel or blood vessels): 3 people, 5.36%
Cryoglobulinaemia (blood contains large amounts of cryoglobulins - proteins): 3 people, 5.36%
Eye Disorder: 3 people, 5.36%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 5.36%
Flatulence (flatus expelled through the anus): 3 people, 5.36%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 3 people, 5.36%
Itching: 2 people, 3.57%
Atrioventricular Block (heart block): 2 people, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and have Enterococcal infection?

- Check whether Enterococcal infection is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diphen:

Diphen (115,432 reports)

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Enterococcal infection:

Enterococcal infection (624 drugs)

Browse all the conditions that are associated with Enterococcal infection:

Enterococcal infection (760 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphen) and Diphen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.