Divalproex sodium and Brain oedema - a phase IV clinical study of FDA data

Summary:

Brain oedema is reported as a side effect among people who take Divalproex sodium (divalproex sodium), especially for people who are female, 20-29 old, also take Diazepam, and have Seizures.

The phase IV clinical study analyzes which people have Brain oedema when taking Divalproex sodium. It is created by eHealthMe based on reports of 9,295 people who have side effects when taking Divalproex sodium from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Brain oedema?

Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain) is found to be associated with 966 drugs and 1,252 conditions by eHealthMe. Check the latest studies of Brain oedema.

On Jul, 11, 2026

9,295 people reported to have side effects when taking Divalproex sodium.
Among them, 37 people (0.4%) have Brain oedema.

Could Divalproex sodium cause Brain oedema?

Among these 37 people:

What is the gender of people who have Brain oedema when taking Divalproex sodium? *

female: 51.35 %
male: 48.65 %

What is the age of people who have Brain oedema when taking Divalproex sodium? *

What are other drugs people take besides Divalproex sodium? *

What are other side effects people have besides Brain oedema? *

Hyperammonaemia: 13 people, 35.14%
Overdose: 9 people, 24.32%
Consciousness - Decreased: 9 people, 24.32%
Brain Herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull): 9 people, 24.32%
Ammonia Increased: 7 people, 18.92%
Hyperammonaemic Encephalopathy (excess of ammonia in the blood, disorder or disease of the brain): 5 people, 13.51%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 10.81%
Hypernatraemia (an abnormally high plasma concentration of sodium ions): 4 people, 10.81%
International Normalised Ratio Increased: 4 people, 10.81%
Encephalopathy (functioning of the brain is affected by some agent or condition): 4 people, 10.81%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 13.51%
Suicide Attempt: 2 people, 5.41%
Immunodeficiency: 2 people, 5.41%
Delusion (a false belief or opinion): 2 people, 5.41%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 5.41%
Blood Insulin Increased: 2 people, 5.41%
Suicidal Ideation: 1 person, 2.70%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 1 person, 2.70%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 2.70%
Neck Pain: 1 person, 2.70%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex sodium and have Brain oedema?

- Check whether Brain oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Divalproex sodium:

Divalproex sodium (9,483 reports)

Brain oedema treatments and more:

Brain oedema (16,340 reports)

Browse all side effects of Divalproex sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain oedema:

Brain oedema (966 drugs)

Browse all the conditions that are associated with Brain oedema:

Brain oedema (1,252 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Divalproex sodium) and Divalproex sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.