Divalproex sodium and Osteoarthritis - a phase IV clinical study of FDA data

Summary:

Osteoarthritis is reported as a side effect among people who take Divalproex sodium (divalproex sodium), especially for people who are female, 60+ old, also take Simvastatin, and have Prostate cancer.

The phase IV clinical study analyzes which people have Osteoarthritis when taking Divalproex sodium. It is created by eHealthMe based on reports of 9,295 people who have side effects when taking Divalproex sodium from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Osteoarthritis?

Osteoarthritis (a joint disease caused by cartilage loss in a joint) is found to be associated with 1,878 drugs and 2,642 conditions by eHealthMe. Check the latest studies of Osteoarthritis.

On Jul, 09, 2026

9,295 people reported to have side effects when taking Divalproex sodium.
Among them, 42 people (0.45%) have Osteoarthritis.

Could Divalproex sodium cause Osteoarthritis?

Among these 42 people:

What is the gender of people who have Osteoarthritis when taking Divalproex sodium? *

female: 52.38 %
male: 47.62 %

What is the age of people who have Osteoarthritis when taking Divalproex sodium? *

What are other drugs people take besides Divalproex sodium? *

Simvastatin: 18 people, 42.86%
Zometa: 15 people, 35.71%
Vicodin: 14 people, 33.33%
Diazepam: 14 people, 33.33%
Hydrochlorothiazide: 14 people, 33.33%
Rosuvastatin Calcium: 14 people, 33.33%
Acetaminophen And Hydrocodone Bitartrate: 13 people, 30.95%
Lipitor: 13 people, 30.95%
Depakote: 12 people, 28.57%
Zestoretic: 11 people, 26.19%

What are other side effects people have besides Osteoarthritis? *

Injury: 20 people, 47.62%
Fatigue (feeling of tiredness): 18 people, 42.86%
Oedema Peripheral (superficial swelling): 18 people, 42.86%
Head Injury: 18 people, 42.86%
Swelling: 17 people, 40.48%
Fall: 16 people, 38.10%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 16 people, 38.10%
Pain In Jaw: 15 people, 35.71%
Osteomyelitis (infection of bone): 15 people, 35.71%
Osteonecrosis Of Jaw (death of bone of jaw): 15 people, 35.71%

What are the existing conditions these people have? *

Prostate Cancer: 10 people, 23.81%
Sleep Disorder: 7 people, 16.67%
High Blood Pressure: 6 people, 14.29%
Nerve Injury: 6 people, 14.29%
Weight Increased: 6 people, 14.29%
Depression: 5 people, 11.90%
Post-Traumatic Stress Disorder: 5 people, 11.90%
Stress And Anxiety: 4 people, 9.52%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 9.52%
Pain: 4 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex sodium and have Osteoarthritis?

- Check whether Osteoarthritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Divalproex sodium:

Divalproex sodium (9,483 reports)

Osteoarthritis treatments and more:

Osteoarthritis (95,654 reports)

Browse all side effects of Divalproex sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoarthritis:

Osteoarthritis (1,878 drugs)

Browse all the conditions that are associated with Osteoarthritis:

Osteoarthritis (2,642 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Divalproex sodium) and Divalproex sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.