Divalproex and Drug effect decreased - a phase IV clinical study of FDA data

Summary:

Drug effect decreased is reported as a side effect among people who take Divalproex (divalproex sodium), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Keppra, and have Seizures.

The phase IV clinical study analyzes which people have Drug effect decreased when taking Divalproex. It is created by eHealthMe based on reports of 13,527 people who have side effects when taking Divalproex from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Drug effect decreased?

Drug effect decreased is found to be associated with 1,454 drugs and 1,918 conditions by eHealthMe. Check the latest studies of Drug effect decreased.

On Aug, 09, 2026

13,527 people reported to have side effects when taking Divalproex.
Among them, 36 people (0.27%) have Drug effect decreased.

Could Divalproex cause Drug effect decreased?

Among these 36 people:

How long have people been on Divalproex when they have Drug effect decreased? *

What is the gender of people who have Drug effect decreased when taking Divalproex? *

female: 51.52 %
male: 48.48 %

What is the age of people who have Drug effect decreased when taking Divalproex? *

What are other drugs people take besides Divalproex? *

What are other side effects people have besides Drug effect decreased? *

Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 11.11%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 11.11%
Weight Decreased: 3 people, 8.33%
Agitation (state of anxiety or nervous excitement): 3 people, 8.33%
Headache (pain in head): 3 people, 8.33%
Drug Ineffective: 3 people, 8.33%
Anger: 3 people, 8.33%
Erythema Multiforme (a type of hypersensitivity reaction): 3 people, 8.33%
Gait Disturbance: 3 people, 8.33%
Muscle Twitching: 3 people, 8.33%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 11.11%
Hypersensitivity: 3 people, 8.33%
Migraine (headache): 3 people, 8.33%
Depression: 2 people, 5.56%
Tardive Dyskinesia (a disorder that involves involuntary movements): 2 people, 5.56%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 5.56%
Rhinorrhea (watery mucus discharge from the nose): 2 people, 5.56%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 5.56%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 5.56%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex and have Drug effect decreased?

- Check whether Drug effect decreased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Divalproex:

Divalproex (14,063 reports)

Browse all side effects of Divalproex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Drug effect decreased:

Drug effect decreased (1,454 drugs)

Browse all the conditions that are associated with Drug effect decreased:

Drug effect decreased (1,918 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Divalproex) and Divalproex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.