Divalproex and Fluid retention - a phase IV clinical study of FDA data

Summary:

Fluid retention is reported as a side effect among people who take Divalproex (divalproex sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Trileptal, and have Depression.

The phase IV clinical study analyzes which people have Fluid retention when taking Divalproex. It is created by eHealthMe based on reports of 13,527 people who have side effects when taking Divalproex from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Fluid retention?

Fluid retention (an abnormal accumulation of fluid in the blood) is found to be associated with 1,700 drugs and 2,447 conditions by eHealthMe. Check the latest studies of Fluid retention.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

13,527 people reported to have side effects when taking Divalproex.
Among them, 25 people (0.18%) have Fluid retention.

Among these 25 people:

How long have people been on Divalproex when they have Fluid retention? *

What is the gender of people who have Fluid retention when taking Divalproex? *

female: 72 %
male: 28 %

What is the age of people who have Fluid retention when taking Divalproex? *

What are other drugs people take besides Divalproex? *

What are other side effects people have besides Fluid retention? *

Abdominal Discomfort: 7 people, 28.00%
Rashes (redness): 7 people, 28.00%
Fatigue (feeling of tiredness): 7 people, 28.00%
Constipation: 7 people, 28.00%
Nausea (feeling of having an urge to vomit): 7 people, 28.00%
Weight Decreased: 7 people, 28.00%
Peripheral Swelling: 7 people, 28.00%
Urinary Tract Infection: 6 people, 24.00%
Stress And Anxiety: 6 people, 24.00%
Diarrhea: 6 people, 24.00%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 24.00%
High Blood Pressure: 6 people, 24.00%
Depression: 6 people, 24.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 20.00%
Pain: 5 people, 20.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 20.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 20.00%
Gastric Disorder (disease of stomach): 5 people, 20.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 20.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 16.00%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex and have Fluid retention?

- Check whether Fluid retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Divalproex:

Divalproex (14,063 reports)

Fluid retention treatments and more:

Fluid retention (79,660 reports)

Browse all side effects of Divalproex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid retention:

Fluid retention (1,700 drugs)

Browse all the conditions that are associated with Fluid retention:

Fluid retention (2,447 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Divalproex) and Divalproex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.