Divalproex and Hepatotoxicity aggravated - a phase IV clinical study of FDA data

Summary:

Hepatotoxicity aggravated is reported as a side effect among people who take Divalproex (divalproex sodium), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Diazepam, and have Depression.

The phase IV clinical study analyzes which people have Hepatotoxicity aggravated when taking Divalproex. It is created by eHealthMe based on reports of 13,527 people who have side effects when taking Divalproex from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Hepatotoxicity aggravated?

Hepatotoxicity aggravated (serious chemical-driven liver damage) is found to be associated with 925 drugs and 413 conditions by eHealthMe. Check the latest studies of Hepatotoxicity aggravated.

On Aug, 11, 2026

13,527 people reported to have side effects when taking Divalproex.
Among them, 113 people (0.84%) have Hepatotoxicity aggravated.

Could Divalproex cause Hepatotoxicity aggravated?

Among these 113 people:

How long have people been on Divalproex when they have Hepatotoxicity aggravated? *

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What is the gender of people who have Hepatotoxicity aggravated when taking Divalproex? *

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What is the age of people who have Hepatotoxicity aggravated when taking Divalproex? *

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* Approximation only. Some reports may have incomplete information.

Do you take Divalproex and have Hepatotoxicity aggravated?

- Check whether Hepatotoxicity aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Divalproex:

Divalproex (14,063 reports)

Hepatotoxicity aggravated treatments and more:

Hepatotoxicity aggravated (47 reports)

How severe was Hepatotoxicity aggravated and when was it recovered:

Hepatotoxicity aggravated in Divalproex

Expand to all the drugs that have ingredients of divalproex sodium:

Hepatotoxicity aggravated and drugs with ingredients of divalproex sodium (184 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Divalproex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatotoxicity aggravated:

Hepatotoxicity aggravated (925 drugs)

Browse all the conditions that are associated with Hepatotoxicity aggravated:

Hepatotoxicity aggravated (413 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Divalproex) and Divalproex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.