Donepezil and Nervous system disorder - a phase IV clinical study of FDA data

Summary:

Nervous system disorder is reported as a side effect among people who take Donepezil (donepezil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Amlodipine Besylate, and have Dementia alzheimer's type.

The phase IV clinical study analyzes which people have Nervous system disorder when taking Donepezil. It is created by eHealthMe based on reports of 24,262 people who have side effects when taking Donepezil from the FDA, and is updated regularly.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

What is Nervous system disorder?

Nervous system disorder (a general class of medical conditions affecting the nervous system) is found to be associated with 1,360 drugs and 1,689 conditions by eHealthMe. Check the latest studies of Nervous system disorder.

On Jul, 10, 2026

24,262 people reported to have side effects when taking Donepezil.
Among them, 30 people (0.12%) have Nervous system disorder.

Could Donepezil cause Nervous system disorder?

Among these 30 people:

How long have people been on Donepezil when they have Nervous system disorder? *

What is the gender of people who have Nervous system disorder when taking Donepezil? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Nervous system disorder when taking Donepezil? *

What are other drugs people take besides Donepezil? *

Clopidogrel: 5 people, 16.67%
Amlodipine Besylate: 5 people, 16.67%
Xyrem: 4 people, 13.33%
Nuedexta: 4 people, 13.33%
Fluoxetine Hydrochloride: 4 people, 13.33%
Omeprazole: 4 people, 13.33%
Hctz: 3 people, 10.00%
Bystolic: 3 people, 10.00%
Crestor: 3 people, 10.00%
Aspirin: 3 people, 10.00%

What are other side effects people have besides Nervous system disorder? *

Depression: 7 people, 23.33%
Weight Decreased: 6 people, 20.00%
Confusional State: 5 people, 16.67%
Insomnia (sleeplessness): 5 people, 16.67%
Heart Attack: 5 people, 16.67%
Weakness: 5 people, 16.67%
Fall: 5 people, 16.67%
Dizziness: 5 people, 16.67%
Gait Disturbance: 4 people, 13.33%
Cardiac Failure Congestive: 4 people, 13.33%

What are the existing conditions these people have? *

Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 7 people, 23.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 13.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 13.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 10.00%
Pain: 3 people, 10.00%
Ovarian Cancer (cancer of ovary): 3 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 10.00%
Joint Pain: 3 people, 10.00%
Drowsiness: 3 people, 10.00%
High Blood Cholesterol: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Donepezil and have Nervous system disorder?

- Check whether Nervous system disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Donepezil:

Donepezil (24,564 reports)

Browse all side effects of Donepezil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nervous system disorder:

Nervous system disorder (1,360 drugs)

Browse all the conditions that are associated with Nervous system disorder:

Nervous system disorder (1,689 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on donepezil hydrochloride (the active ingredients of Donepezil) and Donepezil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.