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Doxycycline hyclate and Mania - a phase IV clinical study of FDA data

Summary:

Mania is reported as a side effect among people who take Doxycycline hyclate (doxycycline hyclate), especially for people who are male, 30-39 old, also take Alprazolam, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Mania when taking Doxycycline hyclate. It is created by eHealthMe based on reports of 16,516 people who have side effects when taking Doxycycline hyclate from the FDA, and is updated regularly.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 17,884 Doxycycline hyclate users. Check the latest studies of Doxycycline hyclate.

What is Mania?

Mania (a state of abnormally elevated or irritable mood) is found to be associated with 924 drugs and 1,157 conditions by eHealthMe. Check the latest studies of Mania.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

16,516 people reported to have side effects when taking Doxycycline hyclate.
Among them, 14 people (0.08%) have Mania.

Could Doxycycline hyclate cause Mania?

Among these 14 people:

What is the gender of people who have Mania when taking Doxycycline hyclate? *

  • female: 35.71 %
  • male: 64.29 %

What is the age of people who have Mania when taking Doxycycline hyclate? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 37.5 %
  • 20-29: 0.0 %
  • 30-39: 37.5 %
  • 40-49: 12.5 %
  • 50-59: 12.5 %
  • 60+: 0.0 %

What are other drugs people take besides Doxycycline hyclate? *

  1. Lorazepam: 7 people, 50.00%
  2. Alprazolam: 7 people, 50.00%
  3. Zyprexa: 6 people, 42.86%
  4. Amoxicillin: 6 people, 42.86%
  5. Effexor Xr: 6 people, 42.86%
  6. Rhinocort: 6 people, 42.86%
  7. Nasonex: 6 people, 42.86%
  8. Viagra: 6 people, 42.86%
  9. Levaquin: 6 people, 42.86%
  10. Wellbutrin Xl: 6 people, 42.86%

What are other side effects people have besides Mania? *

  1. Stress And Anxiety: 9 people, 64.29%
  2. Psychotic Disorder: 7 people, 50.00%
  3. Sleep Disorder: 6 people, 42.86%
  4. Dysstasia (difficulty in standing): 6 people, 42.86%
  5. Nightmares (unpleasant dreams): 6 people, 42.86%
  6. Depression: 6 people, 42.86%
  7. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 6 people, 42.86%
  8. Mental Impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 6 people, 42.86%
  9. Faecal Incontinence (a lack of control over passing stool): 6 people, 42.86%
  10. Suicide Attempt: 6 people, 42.86%

What are the existing conditions these people have? *

  1. Stress And Anxiety: 6 people, 42.86%
  2. Sleep Disorder: 3 people, 21.43%
  3. Pain: 3 people, 21.43%
  4. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 21.43%
  5. Itching: 3 people, 21.43%
  6. High Blood Pressure: 3 people, 21.43%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 21.43%
  8. Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 21.43%
  9. Drowsiness: 3 people, 21.43%
  10. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline hyclate and have Mania?

- Check whether Mania is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline hyclate:

Mania treatments and more:

How severe was Mania and when was it recovered:

Expand to all the drugs that have ingredients of doxycycline hyclate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Doxycycline hyclate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mania:

Browse all the conditions that are associated with Mania:

  • Mania (1,157 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline hyclate) and Doxycycline hyclate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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