Doxycycline and Hypophosphataemia - a phase IV clinical study of FDA data

Summary:

Hypophosphataemia is reported as a side effect among people who take Doxycycline (doxycycline hyclate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Zometa, and have Lambert-eaton syndrome.

The phase IV clinical study analyzes which people have Hypophosphataemia when taking Doxycycline. It is created by eHealthMe based on reports of 57,458 people who have side effects when taking Doxycycline from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Hypophosphataemia?

Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood) is found to be associated with 869 drugs and 782 conditions by eHealthMe. Check the latest studies of Hypophosphataemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

57,458 people reported to have side effects when taking Doxycycline.
Among them, 59 people (0.1%) have Hypophosphataemia.

Could Doxycycline cause Hypophosphataemia?

Among these 59 people:

How long have people been on Doxycycline when they have Hypophosphataemia? *

What is the gender of people who have Hypophosphataemia when taking Doxycycline? *

female: 69.09 %
male: 30.91 %

What is the age of people who have Hypophosphataemia when taking Doxycycline? *

What are other drugs people take besides Doxycycline? *

What are other side effects people have besides Hypophosphataemia? *

Pain: 41 people, 69.49%
Stress And Anxiety: 40 people, 67.80%
Diarrhea: 37 people, 62.71%
Osteonecrosis Of Jaw (death of bone of jaw): 36 people, 61.02%
Thrombocytopenia (decrease of platelets in blood): 35 people, 59.32%
High Blood Pressure: 35 people, 59.32%
Multiple Myeloma (cancer of the plasma cells): 34 people, 57.63%
Hypokalemia (low potassium): 34 people, 57.63%
Headache (pain in head): 34 people, 57.63%
Back Pain: 33 people, 55.93%

What are the existing conditions these people have? *

Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 5 people, 8.47%
Iron Deficiency Anaemia: 4 people, 6.78%
High Blood Pressure: 4 people, 6.78%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 6.78%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.08%
Diabetes: 3 people, 5.08%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 5.08%
Respiratory Tract Infection: 3 people, 5.08%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 5.08%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 2 people, 3.39%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and have Hypophosphataemia?

- Check whether Hypophosphataemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline:

Doxycycline (60,868 reports)

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypophosphataemia:

Hypophosphataemia (869 drugs)

Browse all the conditions that are associated with Hypophosphataemia:

Hypophosphataemia (782 conditions)

Related publications that referenced our studies

Mariappan R, Prasad A, Venkatraghavan L, "An uncommon cause for severe hypophosphataemia after transsphenoidal pituitary surgery", Journal of Neuroanaesthesiology and Critical Care, 2014 May .
Mariappan R, Prasad A, Venkatraghavan L, "An uncommon cause for severe hypophosphataemia after transsphenoidal pituitary surgery", Journal of Neuroanaesthesiology and Critical Care, 2014 May .

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline) and Doxycycline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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