Lenvatinib and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lenvatinib (lenvatinib) and Simvastatin (simvastatin). Common drug interactions include diplopia among females and general physical health deterioration among males.

The phase IV clinical study analyzes what interactions people have when they take Lenvatinib and Simvastatin. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Lenvatinib?

Lenvatinib has active ingredients of lenvatinib. eHealthMe is studying from 3,587 Lenvatinib users. Check the latest studies of Lenvatinib.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

90 people who take Lenvatinib and Simvastatin together, and have interactions are studied.

Lenvatinib and Simvastatin drug interactions.

What are the common drug interactions of Lenvatinib and Simvastatin, by gender? *:

female:

Diplopia (double vision)
Pneumonia
Anaemia (lack of blood)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hypertransaminasaemia
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Pain threshold decreased
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Colitis (inflammation of colon)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

male:

General physical health deterioration (weak health status)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Lacunar infarction (a type of stroke)
Lung abscess (pus in lungs)
Malignant neoplasm progression (cancer tumour came back)
Neutropenia (an abnormally low number of neutrophils)
Ascites (accumulation of fluid in the abdominal cavity)
Dehydration (dryness resulting from the removal of water)
Hepatic failure (liver failure)

What are the common drug interactions of Lenvatinib and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Infusion related reaction
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Neutropenia (an abnormally low number of neutrophils)
Embolism arterial (blood clot that has travelled through your arteries and become stuck)

60+:

Pneumonia
Diplopia (double vision)
Pain threshold decreased
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Asthenia (weakness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Malignant neoplasm progression (cancer tumour came back)
Rash
Renal failure (kidney dysfunction)
Urinary tract infection

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 10 people, 11.11%
Hepatocellular Carcinoma (liver cancer): 10 people, 11.11%
High Blood Pressure: 5 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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