Doxycycline and Retinal detachment - a phase IV clinical study of FDA data

Summary:

Retinal detachment is reported as a side effect among people who take Doxycycline (doxycycline hyclate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Vitamin D3, and have Narcolepsy.

The phase IV clinical study analyzes which people have Retinal detachment when taking Doxycycline. It is created by eHealthMe based on reports of 57,458 people who have side effects when taking Doxycycline from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

What is Retinal detachment?

Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue) is found to be associated with 714 drugs and 1,007 conditions by eHealthMe. Check the latest studies of Retinal detachment.

On Jul, 14, 2026

57,458 people reported to have side effects when taking Doxycycline.
Among them, 44 people (0.08%) have Retinal detachment.

Could Doxycycline cause Retinal detachment?

Among these 44 people:

How long have people been on Doxycycline when they have Retinal detachment? *

What is the gender of people who have Retinal detachment when taking Doxycycline? *

female: 83.72 %
male: 16.28 %

What is the age of people who have Retinal detachment when taking Doxycycline? *

What are other drugs people take besides Doxycycline? *

What are other side effects people have besides Retinal detachment? *

Fluid Retention (an abnormal accumulation of fluid in the blood): 8 people, 18.18%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 7 people, 15.91%
Autonomic Nervous System Imbalance (autonomic nervous system is of net equal emphasis): 7 people, 15.91%
Fall: 7 people, 15.91%
Chest Pain: 7 people, 15.91%
Retinal Haemorrhage (bleeding from retina): 5 people, 11.36%
Vitreous Floaters (spots before the eyes): 5 people, 11.36%
Vision Blurred: 5 people, 11.36%
Hepatic Enzyme Increased: 5 people, 11.36%
Nausea (feeling of having an urge to vomit): 4 people, 9.09%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 22.73%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 11.36%
Malignant Melanoma (skin cancer rises from melancytes): 5 people, 11.36%
Sinusitis (inflammation of sinus): 4 people, 9.09%
Cellulitis (infection under the skin): 4 people, 9.09%
Rashes (redness): 3 people, 6.82%
Depression: 3 people, 6.82%
C-Reactive Protein Increased: 2 people, 4.55%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 2 people, 4.55%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and have Retinal detachment?

- Check whether Retinal detachment is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline:

Doxycycline (60,866 reports)

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Retinal detachment:

Retinal detachment (714 drugs)

Browse all the conditions that are associated with Retinal detachment:

Retinal detachment (1,007 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline) and Doxycycline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.