Duopa and Personality change - a phase IV clinical study of FDA data

Summary:

Personality change is reported as a side effect among people who take Duopa (carbidopa; levodopa), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Nuplazid, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Personality change when taking Duopa. It is created by eHealthMe based on reports of 8,206 people who have side effects when taking Duopa from the FDA, and is updated regularly.

What is Duopa?

Duopa has active ingredients of carbidopa; levodopa. eHealthMe is studying from 8,208 Duopa users. Check the latest studies of Duopa.

What is Personality change?

Personality change is found to be associated with 726 drugs and 947 conditions by eHealthMe. Check the latest studies of Personality change.

On Aug, 09, 2026

8,206 people reported to have side effects when taking Duopa.
Among them, 11 people (0.13%) have Personality change.

Among these 11 people:

How long have people been on Duopa when they have Personality change? *

What is the gender of people who have Personality change when taking Duopa? *

female: 18.18 %
male: 81.82 %

What is the age of people who have Personality change when taking Duopa? *

What are other drugs people take besides Duopa? *

What are other side effects people have besides Personality change? *

Hallucinations (sensations that appear real but are created by your mind): 9 people, 81.82%
Aggression: 8 people, 72.73%
Fall: 6 people, 54.55%
Agitation (state of anxiety or nervous excitement): 5 people, 45.45%
Ventricular Extrasystoles (premature cardiac contraction): 5 people, 45.45%
Flat Affect (absence of emotional response to a situation): 5 people, 45.45%
Loss Of Consciousness: 5 people, 45.45%
Dehydration (dryness resulting from the removal of water): 5 people, 45.45%
Delirium (wild excitement): 5 people, 45.45%
Abnormal Behavior: 4 people, 36.36%

What are the existing conditions these people have? *

Parkinson's Disease: 10 people, 90.91%
Ulcer Haemorrhage (bleeding ulcer): 5 people, 45.45%
Stress And Anxiety: 5 people, 45.45%
Hallucinations (sensations that appear real but are created by your mind): 5 people, 45.45%
Glaucoma (increased fluid pressure in the eye with vision loss): 5 people, 45.45%
Dyskinesia (abnormality or impairment of voluntary movement): 5 people, 45.45%
Sleep Disorder: 2 people, 18.18%
Dementia (madness): 2 people, 18.18%
Thyroid Diseases: 1 person, 9.09%
Prostatic Disorder: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Duopa and have Personality change?

- Check whether Personality change is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Duopa:

Duopa (8,208 reports)

Browse all side effects of Duopa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Personality change:

Personality change (726 drugs)

Browse all the conditions that are associated with Personality change:

Personality change (947 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Duopa) and Duopa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.