Duphalac and Mania - a phase IV clinical study of FDA data

Summary:

Mania is reported as a side effect among people who take Duphalac (lactulose), especially for people who are male, 60+ old, also take Akineton, and have Schizophrenia.

The phase IV clinical study analyzes which people have Mania when taking Duphalac. It is created by eHealthMe based on reports of 5,136 people who have side effects when taking Duphalac from the FDA, and is updated regularly.

What is Duphalac?

Duphalac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 5,152 Duphalac users. Check the latest studies of Duphalac.

What is Mania?

Mania (a state of abnormally elevated or irritable mood) is found to be associated with 924 drugs and 1,157 conditions by eHealthMe. Check the latest studies of Mania.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

5,136 people reported to have side effects when taking Duphalac.
Among them, 18 people (0.35%) have Mania.

Among these 18 people:

What is the gender of people who have Mania when taking Duphalac? *

female: 47.06 %
male: 52.94 %

What is the age of people who have Mania when taking Duphalac? *

What are other drugs people take besides Duphalac? *

What are other side effects people have besides Mania? *

White Blood Cell Count Increased: 4 people, 22.22%
Neutrophil Count Increased (excess than normal number of neutrophil a type of blood cell): 4 people, 22.22%
Alcoholism (problems with alcohol): 4 people, 22.22%
Bleeding Disorders: 4 people, 22.22%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 22.22%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 22.22%
Eschar (dead tissue that falls off (sheds) from healthy skin): 4 people, 22.22%
Gastric Ulcer Haemorrhage (bleeding ulcer of stomach): 4 people, 22.22%
General Physical Health Deterioration (weak health status): 4 people, 22.22%
Logorrhea: 4 people, 22.22%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 22.22%
High Blood Pressure: 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 16.67%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 2 people, 11.11%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 2 people, 11.11%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.56%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 1 person, 5.56%
Depression: 1 person, 5.56%
Cirrhosis Alcoholic (chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue caused by alcoholism): 1 person, 5.56%
Breast Cancer: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Duphalac and have Mania?

- Check whether Mania is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Duphalac:

Duphalac (5,152 reports)

Mania treatments and more:

Mania (24,994 reports)

Browse all side effects of Duphalac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mania:

Mania (924 drugs)

Browse all the conditions that are associated with Mania:

Mania (1,157 conditions)

Related publications that referenced our studies

Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
Pong YH, Lu YC, Tsai VF, Huang PL, Hsieh JT, Chang HC, "Acute manic and psychotic symptoms following subcutaneous leuprolide acetate in a male patient without prior psychiatric history: A case report and literature review", Urological Science, 2014 Mar .
Harris YT, Harris AZ, "Cabergoline associated with first episode mania", Psychosomatics, 2012 Jan .
Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
Pong YH, Lu YC, Tsai VF, Huang PL, Hsieh JT, Chang HC, "Acute manic and psychotic symptoms following subcutaneous leuprolide acetate in a male patient without prior psychiatric history: A case report and literature review", Urological Science, 2014 Mar .
Harris YT, Harris AZ, "Cabergoline associated with first episode mania", Psychosomatics, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on lactulose (the active ingredients of Duphalac) and Duphalac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.