Dupixent and Appendicitis perforated - a phase IV clinical study of FDA data

Summary:

Appendicitis perforated is reported as a side effect among people who take Dupixent (dupilumab), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Acetaminophen, and have Dermatitis atopic.

The phase IV clinical study analyzes which people have Appendicitis perforated when taking Dupixent. It is created by eHealthMe based on reports of 257,518 people who have side effects when taking Dupixent from the FDA, and is updated regularly.

What is Dupixent?

Dupixent has active ingredients of dupilumab. eHealthMe is studying from 257,631 Dupixent users. Check the latest studies of Dupixent.

What is Appendicitis perforated?

Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts) is found to be associated with 362 drugs and 558 conditions by eHealthMe. Check the latest studies of Appendicitis perforated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

257,518 people reported to have side effects when taking Dupixent.
Among them, 11 people (0.0%) have Appendicitis perforated.

Could Dupixent cause Appendicitis perforated?

Among these 11 people:

How long have people been on Dupixent when they have Appendicitis perforated? *

What is the gender of people who have Appendicitis perforated when taking Dupixent? *

female: 50 %
male: 50 %

What is the age of people who have Appendicitis perforated when taking Dupixent? *

What are other drugs people take besides Dupixent? *

Vumerity: 1 person, 9.09%
Montelukast Sodium: 1 person, 9.09%
Lisinopril: 1 person, 9.09%
Fluoxetine Hydrochloride: 1 person, 9.09%
Acetaminophen: 1 person, 9.09%

What are other side effects people have besides Appendicitis perforated? *

Post Procedural Complication: 1 person, 9.09%
Oral Herpes (viral infection of mouth): 1 person, 9.09%
Nausea (feeling of having an urge to vomit): 1 person, 9.09%
Infection: 1 person, 9.09%
Hospitalisation: 1 person, 9.09%
Gastritis (inflammation of stomach): 1 person, 9.09%
Gait Disturbance: 1 person, 9.09%
Eczema Herpeticum (feverish condition and widespread eruption of vesicles): 1 person, 9.09%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 9.09%
Dry Eyes (lack of adequate tears): 1 person, 9.09%

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 7 people, 63.64%
Asthma: 2 people, 18.18%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Dupixent and have Appendicitis perforated?

- Check whether Appendicitis perforated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dupixent:

Dupixent (257,631 reports)

Browse all side effects of Dupixent:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Appendicitis perforated:

Appendicitis perforated (362 drugs)

Browse all the conditions that are associated with Appendicitis perforated:

Appendicitis perforated (558 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dupilumab (the active ingredients of Dupixent) and Dupixent (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.