Dyazide and Agranulocytosis - a phase IV clinical study of FDA data

Summary:

Agranulocytosis is reported as a side effect among people who take Dyazide (hydrochlorothiazide; triamterene), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Decadron, and have Pain.

The phase IV clinical study analyzes which people have Agranulocytosis when taking Dyazide. It is created by eHealthMe based on reports of 11,105 people who have side effects when taking Dyazide from the FDA, and is updated regularly.

What is Dyazide?

Dyazide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 11,506 Dyazide users. Check the latest studies of Dyazide.

What is Agranulocytosis?

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection) is found to be associated with 2,327 drugs and 3,591 conditions by eHealthMe. Check the latest studies of Agranulocytosis.

On Apr, 11, 2026

11,105 people reported to have side effects when taking Dyazide.
Among them, 81 people (0.73%) have Agranulocytosis.

Among these 81 people:

How long have people been on Dyazide when they have Agranulocytosis? *

What is the gender of people who have Agranulocytosis when taking Dyazide? *

female: 85 %
male: 15 %

What is the age of people who have Agranulocytosis when taking Dyazide? *

What are other drugs people take besides Dyazide? *

What are other side effects people have besides Agranulocytosis? *

Thrombocytopenia (decrease of platelets in blood): 19 people, 23.46%
Fever: 19 people, 23.46%
Pleural Effusion (water on the lungs): 16 people, 19.75%
Stress And Anxiety: 15 people, 18.52%
Nausea (feeling of having an urge to vomit): 14 people, 17.28%
Joint Pain: 14 people, 17.28%
Fatigue (feeling of tiredness): 13 people, 16.05%
Anaemia (lack of blood): 13 people, 16.05%
Rashes (redness): 13 people, 16.05%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 12 people, 14.81%

What are the existing conditions these people have? *

Pain: 10 people, 12.35%
Breast Cancer Metastatic: 8 people, 9.88%
Multiple Myeloma (cancer of the plasma cells): 7 people, 8.64%
Breast Cancer: 5 people, 6.17%
Stress And Anxiety: 3 people, 3.70%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 3 people, 3.70%
Nausea (feeling of having an urge to vomit): 3 people, 3.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 3.70%
Lung Adenocarcinoma Metastatic (a form of non-small cell lung cancer spreads to other part): 2 people, 2.47%
Urinary Tract Infection: 2 people, 2.47%

* Approximation only. Some reports may have incomplete information.

Do you take Dyazide and have Agranulocytosis?

- Check whether Agranulocytosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dyazide:

Dyazide (11,506 reports)

Agranulocytosis treatments and more:

Agranulocytosis (213,267 reports)

How severe was Agranulocytosis and when was it recovered:

Agranulocytosis in Dyazide

Expand to all the drugs that have ingredients of hydrochlorothiazide; triamterene:

Agranulocytosis and drugs with ingredients of hydrochlorothiazide; triamterene (210 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dyazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agranulocytosis:

Agranulocytosis (2,327 drugs)

Browse all the conditions that are associated with Agranulocytosis:

Agranulocytosis (3,591 conditions)

Related publications that referenced our studies

Fasullo, S., Davì, S., Cosenza, G., Di Franco, F., La Manna, N., Giubilato, A., ... & Maringhini, G. , "Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature", Journal of thrombosis and thrombolysis, 2018 Jan .
Fasullo, S., Davì, S., Cosenza, G., Di Franco, F., La Manna, N., Giubilato, A., ... & Maringhini, G. , "Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature", Journal of thrombosis and thrombolysis, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; triamterene (the active ingredients of Dyazide) and Dyazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.