Effexor xr and Muscle tightness - a phase IV clinical study of FDA data

Summary:

Muscle tightness is reported as a side effect among people who take Effexor xr (venlafaxine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Neurontin, and have Narcolepsy.

The phase IV clinical study analyzes which people have Muscle tightness when taking Effexor xr. It is created by eHealthMe based on reports of 31,325 people who have side effects when taking Effexor xr from the FDA, and is updated regularly.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

What is Muscle tightness?

Muscle tightness is found to be associated with 1,077 drugs and 1,025 conditions by eHealthMe. Check the latest studies of Muscle tightness.

On Jul, 08, 2026

31,325 people reported to have side effects when taking Effexor xr.
Among them, 76 people (0.24%) have Muscle tightness.

Could Effexor xr cause Muscle tightness?

Among these 76 people:

How long have people been on Effexor xr when they have Muscle tightness? *

What is the gender of people who have Muscle tightness when taking Effexor xr? *

female: 80.26 %
male: 19.74 %

What is the age of people who have Muscle tightness when taking Effexor xr? *

What are other drugs people take besides Effexor xr? *

What are other side effects people have besides Muscle tightness? *

Nausea (feeling of having an urge to vomit): 31 people, 40.79%
Dizziness: 21 people, 27.63%
Headache (pain in head): 21 people, 27.63%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 20 people, 26.32%
Insomnia (sleeplessness): 20 people, 26.32%
Muscle Twitching: 18 people, 23.68%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 17 people, 22.37%
Tremor (trembling or shaking movements in one or more parts of your body): 17 people, 22.37%
Agitation (state of anxiety or nervous excitement): 16 people, 21.05%
Muscle Aches (muscle pain): 16 people, 21.05%

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 5.26%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 5.26%
Headache (pain in head): 3 people, 3.95%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 2.63%
Post-Traumatic Stress Disorder: 2 people, 2.63%
Hepatitis C: 2 people, 2.63%
Asthma: 2 people, 2.63%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 2.63%
High Blood Pressure: 2 people, 2.63%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 2 people, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Effexor xr and have Muscle tightness?

- Check whether Muscle tightness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Effexor xr:

Effexor xr (35,233 reports)

Muscle tightness treatments and more:

Muscle tightness (19,728 reports)

Browse all side effects of Effexor xr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle tightness:

Muscle tightness (1,077 drugs)

Browse all the conditions that are associated with Muscle tightness:

Muscle tightness (1,025 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on venlafaxine hydrochloride (the active ingredients of Effexor xr) and Effexor xr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.