Effexor and Joint instability - a phase IV clinical study of FDA data

Summary:

Joint instability is reported as a side effect among people who take Effexor (venlafaxine hydrochloride), especially for people who are female, 60+ old, also take Albuterol, and have Polymyalgia rheumatica.

The phase IV clinical study analyzes which people have Joint instability when taking Effexor. It is created by eHealthMe based on reports of 92,291 people who have side effects when taking Effexor from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,496 Effexor users. Check the latest studies of Effexor.

What is Joint instability?

Joint instability (a condition in which the joints aren't sufficiently supported) is found to be associated with 230 drugs and 371 conditions by eHealthMe. Check the latest studies of Joint instability.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

92,291 people reported to have side effects when taking Effexor.
Among them, 23 people (0.02%) have Joint instability.

Among these 23 people:

What is the gender of people who have Joint instability when taking Effexor? *

female: 59.09 %
male: 40.91 %

What is the age of people who have Joint instability when taking Effexor? *

What are other drugs people take besides Effexor? *

What are other side effects people have besides Joint instability? *

Joint Pain: 17 people, 73.91%
Gait Disturbance: 17 people, 73.91%
Fatigue (feeling of tiredness): 15 people, 65.22%
Muscle Aches (muscle pain): 15 people, 65.22%
Weakness: 15 people, 65.22%
Joint Range Of Motion Decreased (disease of joint movement): 13 people, 56.52%
Rashes (redness): 13 people, 56.52%
Pain: 12 people, 52.17%
Hyperkeratosis (thickening of the outer layer of the skin): 11 people, 47.83%
Oedema Peripheral (superficial swelling): 11 people, 47.83%

What are the existing conditions these people have? *

Anaemia (lack of blood): 9 people, 39.13%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 9 people, 39.13%
Polymyalgia Rheumatica (pain in many muscles): 9 people, 39.13%
Pain: 7 people, 30.43%
High Blood Cholesterol: 5 people, 21.74%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 21.74%
Hypersensitivity: 4 people, 17.39%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 4 people, 17.39%
Nuclear Magnetic Resonance Imaging Brain: 4 people, 17.39%
Herpes Virus Infection: 4 people, 17.39%

* Approximation only. Some reports may have incomplete information.

Do you take Effexor and have Joint instability?

- Check whether Joint instability is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Effexor:

Effexor (99,496 reports)

Browse all side effects of Effexor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint instability:

Joint instability (230 drugs)

Browse all the conditions that are associated with Joint instability:

Joint instability (371 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on venlafaxine hydrochloride (the active ingredients of Effexor) and Effexor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.