Eliquis and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Eliquis (apixaban), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Cordarone, and have Stroke.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Eliquis. It is created by eHealthMe based on reports of 189,425 people who have side effects when taking Eliquis from the FDA, and is updated regularly.

What is Eliquis?

Eliquis has active ingredients of apixaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 191,788 Eliquis users. Check the latest studies of Eliquis.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,269 drugs and 834 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Oct, 14, 2025

189,425 people reported to have side effects when taking Eliquis.
Among them, 93 people (0.05%) have Sinus node dysfunction.

Could Eliquis cause Sinus node dysfunction?

Among these 93 people:

How long have people been on Eliquis when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Eliquis? *

female: 53.85 %
male: 46.15 %

What is the age of people who have Sinus node dysfunction when taking Eliquis? *

What are other drugs people take besides Eliquis? *

What are other side effects people have besides Sinus node dysfunction? *

Dyspnea (difficult or laboured breathing): 11 people, 11.83%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 10 people, 10.75%
Hyperkalemia (damage to or disease of the kidney): 10 people, 10.75%
Cardiogenic Shock (inadequate circulation of blood): 9 people, 9.68%
Atrioventricular Block (heart block): 9 people, 9.68%
Bradycardia (abnormally slow heart action): 8 people, 8.60%
Fatigue (feeling of tiredness): 7 people, 7.53%
High Blood Pressure: 7 people, 7.53%
Dizziness: 6 people, 6.45%
Fainting (loss of consciousness and postural tone): 6 people, 6.45%

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 16 people, 17.20%
High Blood Pressure: 15 people, 16.13%
Cardiac Failure: 10 people, 10.75%
Acute Pulmonary Oedema (sudden deposit of fluid in the lung)): 9 people, 9.68%
Type 2 Diabetes: 7 people, 7.53%
Constipation: 6 people, 6.45%
Multiple Myeloma (cancer of the plasma cells): 5 people, 5.38%
Dyslipidaemia (abnormal amount of lipids): 4 people, 4.30%
Allergic Rhinitis: 4 people, 4.30%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 4.30%

* Approximation only. Some reports may have incomplete information.

Do you take Eliquis and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Eliquis:

Eliquis (191,788 reports)

Browse all side effects of Eliquis:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,269 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (834 conditions)

Drugs similar to Eliquis and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on apixaban (the active ingredients of Eliquis) and Eliquis (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.