Emend and Intestinal ischaemia - a phase IV clinical study of FDA data

Summary:

Intestinal ischaemia is reported as a side effect among people who take Emend (aprepitant), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Ondansetron, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Intestinal ischaemia when taking Emend. It is created by eHealthMe based on reports of 13,708 people who have side effects when taking Emend from the FDA, and is updated regularly.

What is Emend?

Emend has active ingredients of aprepitant. It is often used in nausea. eHealthMe is studying from 13,741 Emend users. Check the latest studies of Emend.

What is Intestinal ischaemia?

Intestinal ischaemia (decreased supply of oxygenated blood to the intestines) is found to be associated with 676 drugs and 833 conditions by eHealthMe. Check the latest studies of Intestinal ischaemia.

On Aug, 06, 2026

13,708 people reported to have side effects when taking Emend.
Among them, 38 people (0.28%) have Intestinal ischaemia.

Among these 38 people:

How long have people been on Emend when they have Intestinal ischaemia? *

What is the gender of people who have Intestinal ischaemia when taking Emend? *

female: 32.43 %
male: 67.57 %

What is the age of people who have Intestinal ischaemia when taking Emend? *

What are other drugs people take besides Emend? *

What are other side effects people have besides Intestinal ischaemia? *

Thrombocytopenia (decrease of platelets in blood): 15 people, 39.47%
Anaemia (lack of blood): 10 people, 26.32%
Acute Kidney Failure: 6 people, 15.79%
Septic Shock (shock due to blood infection): 6 people, 15.79%
Dermatitis Bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid): 5 people, 13.16%
Aplasia (defective development or congenital absence of an organ or tissue): 5 people, 13.16%
International Normalised Ratio Increased: 4 people, 10.53%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 4 people, 10.53%
Blood Bilirubin Increased: 4 people, 10.53%
Activated Partial Thromboplastin Time Prolonged: 4 people, 10.53%

What are the existing conditions these people have? *

Oesophageal Squamous Cell Carcinoma Metastatic (cancer that begins in flat cells lining the oesophagus spreads to other part): 10 people, 26.32%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 26.32%
Acute Leukaemia (blood cancer): 5 people, 13.16%
Oral Cancer (mouth cancer): 4 people, 10.53%
Small Cell Lung Cancer Extensive Stage (small cell lung cancer that has spread (metastasized) to other regions of the body such as another lobe of the lung or the brain): 3 people, 7.89%
Breast Cancer: 3 people, 7.89%
Device Occlusion: 2 people, 5.26%
Bone Marrow Conditioning Regimen: 2 people, 5.26%
Abdominal Pain Upper: 2 people, 5.26%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Emend and have Intestinal ischaemia?

- Check whether Intestinal ischaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Emend:

Emend (13,741 reports)

Browse all side effects of Emend:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intestinal ischaemia:

Intestinal ischaemia (676 drugs)

Browse all the conditions that are associated with Intestinal ischaemia:

Intestinal ischaemia (833 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on aprepitant (the active ingredients of Emend) and Emend (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.