Emend and Syncope - a phase IV clinical study of FDA data

Summary:

Syncope is reported as a side effect among people who take Emend (aprepitant), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Zofran, and have Hypertonia.

The phase IV clinical study analyzes which people have Syncope when taking Emend. It is created by eHealthMe based on reports of 13,708 people who have side effects when taking Emend from the FDA, and is updated regularly.

What is Emend?

Emend has active ingredients of aprepitant. It is often used in nausea. eHealthMe is studying from 13,741 Emend users. Check the latest studies of Emend.

What is Syncope?

Syncope (loss of consciousness with an inability to maintain postural tone) is found to be associated with 3,441 drugs and 3,518 conditions by eHealthMe. Check the latest studies of Syncope.

On Feb, 11, 2026

13,708 people reported to have side effects when taking Emend.
Among them, 122 people (0.89%) have Syncope.

Among these 122 people:

* Approximation only. Some reports may have incomplete information.

Do you take Emend and have Syncope?

- Check whether Syncope is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Emend:

Emend (13,741 reports)

Syncope treatments and more:

Syncope (131,321 reports)

How severe was Syncope and when was it recovered:

Syncope in Emend

Expand to all the drugs that have ingredients of aprepitant:

Syncope and drugs with ingredients of aprepitant (94 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Emend:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Syncope:

Syncope (3,441 drugs)

Browse all the conditions that are associated with Syncope:

Syncope (3,518 conditions)

Related publications that referenced our studies

Dubrey SW, VanGriethuysen J, Edwards CM, "A hairy fall: syncope resulting from topical application of minoxidil", BMJ case reports, 2015 Sep .
Dubrey SW, VanGriethuysen J, Edwards CM, "A hairy fall: syncope resulting from topical application of minoxidil", BMJ case reports, 2015 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on aprepitant (the active ingredients of Emend) and Emend (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.