Enbrel and Musculoskeletal stiffness - a phase IV clinical study of FDA data

Summary:

Musculoskeletal stiffness is reported as a side effect among people who take Enbrel (etanercept), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Humira, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Musculoskeletal stiffness when taking Enbrel. It is created by eHealthMe based on reports of 662,905 people who have side effects when taking Enbrel from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,677 Enbrel users. Check the latest studies of Enbrel.

What is Musculoskeletal stiffness?

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves) is found to be associated with 1,961 drugs and 1,913 conditions by eHealthMe. Check the latest studies of Musculoskeletal stiffness.

On Jan, 20, 2026

662,905 people reported to have side effects when taking Enbrel.
Among them, 17,807 people (2.69%) have Musculoskeletal stiffness.

Could Enbrel cause Musculoskeletal stiffness?

Among these 17,807 people:

How long have people been on Enbrel when they have Musculoskeletal stiffness? *

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What is the gender of people who have Musculoskeletal stiffness when taking Enbrel? *

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What is the age of people who have Musculoskeletal stiffness when taking Enbrel? *

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* Approximation only. Some reports may have incomplete information.

Do you take Enbrel and have Musculoskeletal stiffness?

- Check whether Musculoskeletal stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Enbrel:

Enbrel (664,677 reports)

Musculoskeletal stiffness treatments and more:

Musculoskeletal stiffness (106,467 reports)

How severe was Musculoskeletal stiffness and when was it recovered:

Musculoskeletal stiffness in Enbrel

Expand to all the drugs that have ingredients of etanercept:

Musculoskeletal stiffness and drugs with ingredients of etanercept (6,889 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Enbrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,961 drugs)

Browse all the conditions that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,913 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on etanercept (the active ingredients of Enbrel) and Enbrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.