Enbrel and Uterine prolapse - a phase IV clinical study of FDA data

Summary:

Uterine prolapse is reported as a side effect among people who take Enbrel (etanercept), especially for people who are 60+ old, have been taking the drug for 5 - 10 years also take Plaquenil, and have Psoriasis.

The phase IV clinical study analyzes which people have Uterine prolapse when taking Enbrel. It is created by eHealthMe based on reports of 662,905 people who have side effects when taking Enbrel from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

What is Uterine prolapse?

Uterine prolapse is found to be associated with 223 drugs and 469 conditions by eHealthMe. Check the latest studies of Uterine prolapse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 03, 2026

662,905 people reported to have side effects when taking Enbrel.
Among them, 48 people (0.01%) have Uterine prolapse.

Could Enbrel cause Uterine prolapse?

Among these 48 people:

How long have people been on Enbrel when they have Uterine prolapse? *

  • < 1 month: 12.5 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 12.5 %
  • 1 - 2 years: 25.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 37.5 %
  • 10+ years: 12.5 %

What is the age of people who have Uterine prolapse when taking Enbrel? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 3.03 %
  • 40-49: 39.39 %
  • 50-59: 12.12 %
  • 60+: 45.45 %

What are other drugs people take besides Enbrel? *

  1. Methotrexate: 4 people, 8.33%
  2. Fosamax: 4 people, 8.33%
  3. Folic Acid: 4 people, 8.33%
  4. Plaquenil: 4 people, 8.33%
  5. Remicade: 2 people, 4.17%
  6. Methotrexate Sodium: 2 people, 4.17%
  7. Hydrochlorothiazide: 2 people, 4.17%
  8. Humira: 2 people, 4.17%
  9. Oxybutynin Chloride: 2 people, 4.17%
  10. Prempro: 2 people, 4.17%

What are other side effects people have besides Uterine prolapse? *

  1. Bladder Prolapse (bulging of one or more of the pelvic organs into the vagina): 11 people, 22.92%
  2. Joint Pain: 8 people, 16.67%
  3. Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth): 7 people, 14.58%
  4. Joint Swelling: 6 people, 12.50%
  5. Psoriasis (immune-mediated disease that affects the skin): 6 people, 12.50%
  6. Injection Site Pain: 5 people, 10.42%
  7. Pain: 5 people, 10.42%
  8. Oedema Peripheral (superficial swelling): 5 people, 10.42%
  9. Malaise (a feeling of general discomfort or uneasiness): 5 people, 10.42%
  10. Fatigue (feeling of tiredness): 4 people, 8.33%

What are the existing conditions these people have? *

  1. Psoriasis (immune-mediated disease that affects the skin): 8 people, 16.67%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 14.58%
  3. Osteoporosis (bones weak and more likely to break): 3 people, 6.25%
  4. Pain: 2 people, 4.17%
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 4.17%
  6. Stress And Anxiety: 1 person, 2.08%
  7. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 2.08%
  8. Metastases To Spine (cancer spreads to spine): 1 person, 2.08%
  9. Metastases To Bone (cancer spreads to bone): 1 person, 2.08%
  10. High Blood Pressure: 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Enbrel and have Uterine prolapse?

- Check whether Uterine prolapse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Enbrel:

Uterine prolapse treatments and more:

How severe was Uterine prolapse and when was it recovered:

Expand to all the drugs that have ingredients of etanercept:

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Enbrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Uterine prolapse:

Browse all the conditions that are associated with Uterine prolapse:


How the study uses the data?

The study uses data from the FDA. It is based on etanercept (the active ingredients of Enbrel) and Enbrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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