Acetaminophen and Paliperidone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetaminophen (acetaminophen) and Paliperidone (paliperidone). Common drug interactions include cerebral infarction among females and neuroleptic malignant syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Acetaminophen and Paliperidone. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

What is Paliperidone?

Paliperidone has active ingredients of paliperidone. eHealthMe is studying from 5,137 Paliperidone users. Check the latest studies of Paliperidone.

eHealthMe: drug outcomes in the real world

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On Aug, 24, 2026

34 people who take Acetaminophen and Paliperidone together, and have interactions are studied.

Acetaminophen and Paliperidone drug interactions.

What are the common drug interactions of Acetaminophen and Paliperidone, by gender? *:

female:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Coma (state of unconsciousness lasting more than six hours)
Locked-in syndrome (a condition in which a patient is aware and awake but cannot move or communicate verbally due to complete paralysis)
Multiple drug overdose
Death
Pickwickian syndrome (extreme obesity accompanied by sleepiness, hypoventilation, and polycythemia)
Vomiting
Abscess (pus)
Back pain
Balance disorder

male:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Drug ineffective
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)
Agitation (state of anxiety or nervous excitement)
Bezoar (mass found trapped in the gastrointestinal system)
Blood creatine phosphokinase increased
Cardiac arrest
Dizziness

What are the common drug interactions of Acetaminophen and Paliperidone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)

20-29:

Overdose
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Drug abuse
Drug ineffective
Bezoar (mass found trapped in the gastrointestinal system)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)

30-39:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Coma (state of unconsciousness lasting more than six hours)
Locked-in syndrome (a condition in which a patient is aware and awake but cannot move or communicate verbally due to complete paralysis)
Multiple drug overdose
Death
Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Atelectasis (partial or complete collapse of the lung)
Drug ineffective

40-49:

Dyspnoea (difficult or laboured respiration)
Pickwickian syndrome (extreme obesity accompanied by sleepiness, hypoventilation, and polycythemia)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Weight increased
Agitation (state of anxiety or nervous excitement)
Asthma
Atrioventricular block second degree (heart block second degree)
Blood creatine phosphokinase increased
C-reactive protein increased
Cardiac arrest

50-59:

Back pain
Balance disorder
Bipolar disorder (mood disorder)
Hallucination (an experience involving the perception of something not present)
Cardiac arrest
Granulocytopenia (lack of granulocyte)
Leukopenia (less number of white blood cells in blood)
Loss of consciousness
Overdose
Peripheral swelling

60+:

Abscess (pus)
Cardiac murmur (an heart sound in valve abnormality)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Sepsis (a severe blood infection that can lead to organ failure and death)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dizziness
Facial paralysis (loss of function of face muscle)
Hyperglycaemic hyperosmolar nonketotic syndrome (too much sugar (glucose) in your blood)
Platelet count decreased
Pyrexia (fever)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 13 people, 38.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 11.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 11.76%
Type 2 Diabetes: 3 people, 8.82%
Headache (pain in head): 3 people, 8.82%
Agitation (state of anxiety or nervous excitement): 3 people, 8.82%
Asthma: 3 people, 8.82%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 3 people, 8.82%
Constipation: 3 people, 8.82%
Depression: 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

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