Entacapone and Extrapyramidal disorder - a phase IV clinical study of FDA data

Summary:

Extrapyramidal disorder is reported as a side effect among people who take Entacapone (entacapone), especially for people who are male, 60+ old, also take Diclofenac, and have Back pain.

The phase IV clinical study analyzes which people have Extrapyramidal disorder when taking Entacapone. It is created by eHealthMe based on reports of 4,239 people who have side effects when taking Entacapone from the FDA, and is updated regularly.

What is Entacapone?

Entacapone has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 4,261 Entacapone users. Check the latest studies of Entacapone.

What is Extrapyramidal disorder?

Extrapyramidal disorder (involuntary muscle spasms in the face and neck) is found to be associated with 809 drugs and 960 conditions by eHealthMe. Check the latest studies of Extrapyramidal disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

4,239 people reported to have side effects when taking Entacapone.
Among them, 24 people (0.57%) have Extrapyramidal disorder.

Could Entacapone cause Extrapyramidal disorder?

Among these 24 people:

What is the gender of people who have Extrapyramidal disorder when taking Entacapone? *

female: 9.09 %
male: 90.91 %

What is the age of people who have Extrapyramidal disorder when taking Entacapone? *

What are other drugs people take besides Entacapone? *

What are other side effects people have besides Extrapyramidal disorder? *

Pancreatitis Acute (sudden inflammation of pancreas): 19 people, 79.17%
Abdominal Pain Upper: 13 people, 54.17%
Amylase Increased: 2 people, 8.33%
Lipase Increased: 2 people, 8.33%
Parkinsonism Aggravated (a degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination): 1 person, 4.17%
Pancreatitis (inflammation of pancreas): 1 person, 4.17%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 1 person, 4.17%
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 1 person, 4.17%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1 person, 4.17%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 1 person, 4.17%

What are the existing conditions these people have? *

Back Pain: 20 people, 83.33%
Diabetes: 2 people, 8.33%
Dizziness: 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Entacapone and have Extrapyramidal disorder?

- Check whether Extrapyramidal disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Entacapone:

Entacapone (4,261 reports)

Browse all side effects of Entacapone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Extrapyramidal disorder:

Extrapyramidal disorder (809 drugs)

Browse all the conditions that are associated with Extrapyramidal disorder:

Extrapyramidal disorder (960 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on entacapone (the active ingredients of Entacapone) and Entacapone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.