Entacapone and Irritability - a phase IV clinical study of FDA data

Summary:

Irritability is reported as a side effect among people who take Entacapone (entacapone), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Sertraline, and have Major depression.

The phase IV clinical study analyzes which people have Irritability when taking Entacapone. It is created by eHealthMe based on reports of 4,239 people who have side effects when taking Entacapone from the FDA, and is updated regularly.

What is Entacapone?

Entacapone has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 4,261 Entacapone users. Check the latest studies of Entacapone.

What is Irritability?

Irritability is found to be associated with 1,698 drugs and 2,458 conditions by eHealthMe. Check the latest studies of Irritability.

On Jul, 24, 2026

4,239 people reported to have side effects when taking Entacapone.
Among them, 66 people (1.56%) have Irritability.

Among these 66 people:

How long have people been on Entacapone when they have Irritability? *

What is the gender of people who have Irritability when taking Entacapone? *

female: 32.31 %
male: 67.69 %

What is the age of people who have Irritability when taking Entacapone? *

What are other drugs people take besides Entacapone? *

Sertraline: 25 people, 37.88%
Nuplazid: 10 people, 15.15%
Sinemet: 9 people, 13.64%
Carbidopa And Levodopa: 8 people, 12.12%
Amlodipine: 7 people, 10.61%
Ativan: 6 people, 9.09%
Inbrija: 6 people, 9.09%
Droxidopa: 5 people, 7.58%
Kynmobi: 5 people, 7.58%
Flexeril: 5 people, 7.58%

What are other side effects people have besides Irritability? *

Aggression: 33 people, 50.00%
Insomnia (sleeplessness): 32 people, 48.48%
Psychomotor Hyperactivity (feelings of extreme restlessness): 28 people, 42.42%
Energy Increased: 27 people, 40.91%
Logorrhea: 26 people, 39.39%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 26 people, 39.39%
Agitation (state of anxiety or nervous excitement): 18 people, 27.27%
Mania (a state of abnormally elevated or irritable mood): 18 people, 27.27%
Mood Swings (an extreme or rapid change in mood): 17 people, 25.76%
Confusion: 14 people, 21.21%

What are the existing conditions these people have? *

Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 26 people, 39.39%
Depression: 18 people, 27.27%
Hallucinations (sensations that appear real but are created by your mind): 11 people, 16.67%
High Blood Pressure: 8 people, 12.12%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 6 people, 9.09%
Stress And Anxiety: 6 people, 9.09%
Delusion (a false belief or opinion): 5 people, 7.58%
Psychotic Disorder Due To A General Medical Condition: 4 people, 6.06%
Dementia With Lewy Bodies (progressive degenerative disease or syndrome of the brain): 3 people, 4.55%
Psychotic Disorder: 2 people, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Entacapone and have Irritability?

- Check whether Irritability is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Entacapone:

Entacapone (4,261 reports)

Irritability treatments and more:

Irritability (71,614 reports)

Browse all side effects of Entacapone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irritability:

Irritability (1,698 drugs)

Browse all the conditions that are associated with Irritability:

Irritability (2,458 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on entacapone (the active ingredients of Entacapone) and Entacapone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.