Epidiolex and Musculoskeletal stiffness - a phase IV clinical study of FDA data

Summary:

Musculoskeletal stiffness is reported as a side effect among people who take Epidiolex (cannabidiol), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Melatonin, and have Epilepsy.

The phase IV clinical study analyzes which people have Musculoskeletal stiffness when taking Epidiolex. It is created by eHealthMe based on reports of 18,738 people who have side effects when taking Epidiolex from the FDA, and is updated regularly.

What is Epidiolex?

Epidiolex has active ingredients of cannabidiol. eHealthMe is studying from 18,763 Epidiolex users. Check the latest studies of Epidiolex.

What is Musculoskeletal stiffness?

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves) is found to be associated with 1,959 drugs and 1,916 conditions by eHealthMe. Check the latest studies of Musculoskeletal stiffness.

On Jul, 18, 2026

18,738 people reported to have side effects when taking Epidiolex.
Among them, 14 people (0.07%) have Musculoskeletal stiffness.

Could Epidiolex cause Musculoskeletal stiffness?

Among these 14 people:

How long have people been on Epidiolex when they have Musculoskeletal stiffness? *

What is the gender of people who have Musculoskeletal stiffness when taking Epidiolex? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Musculoskeletal stiffness when taking Epidiolex? *

What are other drugs people take besides Epidiolex? *

What are other side effects people have besides Musculoskeletal stiffness? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 28.57%
Fatigue (feeling of tiredness): 4 people, 28.57%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 28.57%
Drowsiness: 3 people, 21.43%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 21.43%
Weakness: 2 people, 14.29%
Pain In Extremity: 2 people, 14.29%
Crying: 2 people, 14.29%
Depressed Level Of Consciousness: 2 people, 14.29%
Drooling (drop saliva uncontrollably from the mouth): 2 people, 14.29%

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 7 people, 50.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 21.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
Partial Seizures (seizures which affect only a part of the brain at onset): 2 people, 14.29%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 2 people, 14.29%
Insomnia (sleeplessness): 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%
Dermatitis Diaper (diaper rash is a common form of inflamed skin): 1 person, 7.14%
Constipation: 1 person, 7.14%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Epidiolex and have Musculoskeletal stiffness?

- Check whether Musculoskeletal stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Epidiolex:

Epidiolex (18,763 reports)

Browse all side effects of Epidiolex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,959 drugs)

Browse all the conditions that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,916 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cannabidiol (the active ingredients of Epidiolex) and Epidiolex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.