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Epipen and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Epipen (epinephrine), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Benadryl, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Epipen. It is created by eHealthMe based on reports of 23,690 people who have side effects when taking Epipen from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,088 drugs and 1,358 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

On Jul, 16, 2026

23,690 people reported to have side effects when taking Epipen.
Among them, 67 people (0.28%) have Multiple sclerosis.

Could Epipen cause Multiple sclerosis?

Among these 67 people:

How long have people been on Epipen when they have Multiple sclerosis? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Multiple sclerosis when taking Epipen? *

  • female: 96.67 %
  • male: 3.33 %

What is the age of people who have Multiple sclerosis when taking Epipen? *

  • 0-1: 0.0 %
  • 2-9: 2.44 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 9.76 %
  • 40-49: 14.63 %
  • 50-59: 63.41 %
  • 60+: 9.76 %

What are other drugs people take besides Epipen? *

  1. Benadryl: 32 people, 47.76%
  2. Cymbalta: 26 people, 38.81%
  3. Lyrica: 26 people, 38.81%
  4. Cetirizine Hydrochloride: 26 people, 38.81%
  5. Medrol: 25 people, 37.31%
  6. Atenolol: 24 people, 35.82%
  7. Prednisone: 23 people, 34.33%
  8. Zopiclone: 22 people, 32.84%
  9. Prevacid: 22 people, 32.84%
  10. Duloxetine Hydrochloride: 22 people, 32.84%

What are other side effects people have besides Multiple sclerosis? *

  1. Fatigue (feeling of tiredness): 31 people, 46.27%
  2. Weakness: 30 people, 44.78%
  3. Dizziness: 30 people, 44.78%
  4. Nausea (feeling of having an urge to vomit): 29 people, 43.28%
  5. Balance Disorder: 29 people, 43.28%
  6. Pain: 27 people, 40.30%
  7. Joint Pain: 27 people, 40.30%
  8. Fall: 27 people, 40.30%
  9. Drug Ineffective: 27 people, 40.30%
  10. Depression: 26 people, 38.81%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 18 people, 26.87%
  2. Hypersensitivity: 16 people, 23.88%
  3. Sleep Disorder: 9 people, 13.43%
  4. Wheezing (a high-pitched whistling sound made while you breath): 5 people, 7.46%
  5. Pain: 5 people, 7.46%
  6. Dizziness: 5 people, 7.46%
  7. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 7.46%
  8. Abdominal Pain: 4 people, 5.97%
  9. Affective Disorder (mental disorder): 4 people, 5.97%
  10. Dry Mouth: 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

Do you take Epipen and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Epipen:

Multiple sclerosis treatments and more:

How severe was Multiple sclerosis and when was it recovered:

Expand to all the drugs that have ingredients of epinephrine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Browse all the conditions that are associated with Multiple sclerosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on epinephrine (the active ingredients of Epipen) and Epipen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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