Epipen and Osteoarthritis - a phase IV clinical study of FDA data

Summary:

Osteoarthritis is reported as a side effect among people who take Epipen (epinephrine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Osteoarthritis when taking Epipen. It is created by eHealthMe based on reports of 23,690 people who have side effects when taking Epipen from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Osteoarthritis?

Osteoarthritis (a joint disease caused by cartilage loss in a joint) is found to be associated with 1,877 drugs and 2,645 conditions by eHealthMe. Check the latest studies of Osteoarthritis.

On May, 06, 2026

23,690 people reported to have side effects when taking Epipen.
Among them, 90 people (0.38%) have Osteoarthritis.

Among these 90 people:

How long have people been on Epipen when they have Osteoarthritis? *

What is the gender of people who have Osteoarthritis when taking Epipen? *

female: 75.29 %
male: 24.71 %

What is the age of people who have Osteoarthritis when taking Epipen? *

What are other drugs people take besides Epipen? *

What are other side effects people have besides Osteoarthritis? *

Joint Pain: 28 people, 31.11%
Fall: 27 people, 30.00%
Pain: 26 people, 28.89%
Back Pain: 26 people, 28.89%
Headache (pain in head): 24 people, 26.67%
Pain In Extremity: 24 people, 26.67%
Dizziness: 22 people, 24.44%
High Blood Pressure: 21 people, 23.33%
Insomnia (sleeplessness): 19 people, 21.11%
Dyspnea (difficult or laboured breathing): 18 people, 20.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 17 people, 18.89%
Asthma: 15 people, 16.67%
Pain: 14 people, 15.56%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 15.56%
Hypersensitivity: 13 people, 14.44%
High Blood Cholesterol: 13 people, 14.44%
Allergy To Arthropod Sting: 12 people, 13.33%
High Blood Pressure: 11 people, 12.22%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 10.00%
Osteoporosis (bones weak and more likely to break): 7 people, 7.78%

* Approximation only. Some reports may have incomplete information.

Do you take Epipen and have Osteoarthritis?

- Check whether Osteoarthritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Epipen:

Epipen (23,760 reports)

Osteoarthritis treatments and more:

Osteoarthritis (95,654 reports)

Browse all side effects of Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoarthritis:

Osteoarthritis (1,877 drugs)

Browse all the conditions that are associated with Osteoarthritis:

Osteoarthritis (2,645 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on epinephrine (the active ingredients of Epipen) and Epipen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.