Epival and Hypersomnia - a phase IV clinical study of FDA data

Summary:

Hypersomnia is reported as a side effect among people who take Epival (divalproex sodium), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Abilify, and have Depression.

The phase IV clinical study analyzes which people have Hypersomnia when taking Epival. It is created by eHealthMe based on reports of 968 people who have side effects when taking Epival from the FDA, and is updated regularly.

What is Epival?

Epival has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 1,088 Epival users. Check the latest studies of Epival.

What is Hypersomnia?

Hypersomnia (excessive daytime sleepiness (eds)) is found to be associated with 3,127 drugs and 4,824 conditions by eHealthMe. Check the latest studies of Hypersomnia.

On May, 07, 2026

968 people reported to have side effects when taking Epival.
Among them, 96 people (9.92%) have Hypersomnia.

Among these 96 people:

How long have people been on Epival when they have Hypersomnia? *

What is the gender of people who have Hypersomnia when taking Epival? *

female: 78.49 %
male: 21.51 %

What is the age of people who have Hypersomnia when taking Epival? *

What are other drugs people take besides Epival? *

What are other side effects people have besides Hypersomnia? *

Weight Increased: 52 people, 54.17%
Hair Loss: 31 people, 32.29%
Fatigue (feeling of tiredness): 30 people, 31.25%
Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 13 people, 13.54%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 12 people, 12.50%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 12 people, 12.50%
Pain In Extremity: 10 people, 10.42%
Confusional State: 10 people, 10.42%
Hoarseness Or Changing Voice: 9 people, 9.38%
Aphonia (inability to produce voice): 9 people, 9.38%

What are the existing conditions these people have? *

Depression: 35 people, 36.46%
Stress And Anxiety: 30 people, 31.25%
Psychotic Disorder: 10 people, 10.42%
High Blood Cholesterol: 6 people, 6.25%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 5 people, 5.21%
Migraine (headache): 5 people, 5.21%
Sleep Disorder: 5 people, 5.21%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 4.17%
Seasonal Affective Disorder (a type of depression that occurs at a certain time of the year, usually in the winter): 4 people, 4.17%
Primary Immunodeficiency Syndrome: 4 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Epival and have Hypersomnia?

- Check whether Hypersomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Epival:

Epival (1,088 reports)

Hypersomnia treatments and more:

Hypersomnia (269,040 reports)

Browse all side effects of Epival:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypersomnia:

Hypersomnia (3,127 drugs)

Browse all the conditions that are associated with Hypersomnia:

Hypersomnia (4,824 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Epival) and Epival (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.