Escitalopram and Neurological decompensation - a phase IV clinical study of FDA data

Summary:

Neurological decompensation is reported as a side effect among people who take Escitalopram (escitalopram oxalate), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Fluoxetine, and have Suicide attempt.

The phase IV clinical study analyzes which people have Neurological decompensation when taking Escitalopram. It is created by eHealthMe based on reports of 75,134 people who have side effects when taking Escitalopram from the FDA, and is updated regularly.

What is Escitalopram?

Escitalopram has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 78,081 Escitalopram users. Check the latest studies of Escitalopram.

What is Neurological decompensation?

Neurological decompensation (inability of brain to maintain proper function) is found to be associated with 262 drugs and 451 conditions by eHealthMe. Check the latest studies of Neurological decompensation.

On Aug, 07, 2026

75,134 people reported to have side effects when taking Escitalopram.
Among them, 23 people (0.03%) have Neurological decompensation.

Could Escitalopram cause Neurological decompensation?

Among these 23 people:

How long have people been on Escitalopram when they have Neurological decompensation? *

What is the gender of people who have Neurological decompensation when taking Escitalopram? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Neurological decompensation when taking Escitalopram? *

What are other drugs people take besides Escitalopram? *

What are other side effects people have besides Neurological decompensation? *

Urinary Incontinence (inability to control the flow of urine and involuntary urination): 6 people, 26.09%
Drug Ineffective: 6 people, 26.09%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 21.74%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 5 people, 21.74%
Depressed Mood: 5 people, 21.74%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 5 people, 21.74%
Insomnia (sleeplessness): 5 people, 21.74%
Catatonia (unresponsive to external stimuli): 5 people, 21.74%
Melaena (the passage of black, tarry stools): 5 people, 21.74%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 5 people, 21.74%

What are the existing conditions these people have? *

Suicide Attempt: 6 people, 26.09%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 5 people, 21.74%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 17.39%
Schizotypal Personality Disorder (a personality disorder characterized by a need for social isolation, anxiety in social situations): 3 people, 13.04%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 3 people, 13.04%
Mania (a state of abnormally elevated or irritable mood): 3 people, 13.04%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 8.70%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 8.70%
Urinary Tract Disorder: 1 person, 4.35%
Sleep Disorder: 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Escitalopram and have Neurological decompensation?

- Check whether Neurological decompensation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Escitalopram:

Escitalopram (78,081 reports)

Browse all side effects of Escitalopram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Neurological decompensation:

Neurological decompensation (262 drugs)

Browse all the conditions that are associated with Neurological decompensation:

Neurological decompensation (451 conditions)

Related publications that referenced our studies

O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on escitalopram oxalate (the active ingredients of Escitalopram) and Escitalopram (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.