Estrace and Cardiac disorder - a phase IV clinical study of FDA data

Summary:

Cardiac disorder is reported as a side effect among people who take Estrace (estradiol), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Synthroid, and have Osteoporosis.

The phase IV clinical study analyzes which people have Cardiac disorder when taking Estrace. It is created by eHealthMe based on reports of 16,282 people who have side effects when taking Estrace from the FDA, and is updated regularly.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

What is Cardiac disorder?

Cardiac disorder is found to be associated with 2,042 drugs and 1,960 conditions by eHealthMe. Check the latest studies of Cardiac disorder.

On Jul, 14, 2026

16,282 people reported to have side effects when taking Estrace.
Among them, 84 people (0.52%) have Cardiac disorder.

Among these 84 people:

How long have people been on Estrace when they have Cardiac disorder? *

What is the gender of people who have Cardiac disorder when taking Estrace? *

female: 100 %
male: 0.0 %

What is the age of people who have Cardiac disorder when taking Estrace? *

What are other drugs people take besides Estrace? *

What are other side effects people have besides Cardiac disorder? *

Chest Pain: 23 people, 27.38%
High Blood Cholesterol: 21 people, 25.00%
Fatigue (feeling of tiredness): 20 people, 23.81%
Joint Pain: 18 people, 21.43%
High Blood Pressure: 16 people, 19.05%
Muscle Spasms (muscle contraction): 15 people, 17.86%
Stable Angina (a constant chest pain): 15 people, 17.86%
Fall: 14 people, 16.67%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 14 people, 16.67%
Femur Fracture: 14 people, 16.67%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 14 people, 16.67%
Osteopenia (a condition where bone mineral density is lower than normal): 13 people, 15.48%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 10.71%
High Blood Cholesterol: 9 people, 10.71%
Back Pain: 9 people, 10.71%
Thyroid Diseases: 6 people, 7.14%
Infection: 6 people, 7.14%
Diabetes: 6 people, 7.14%
Giant Cell Tumor Of Tendon Sheath: 4 people, 4.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Estrace and have Cardiac disorder?

- Check whether Cardiac disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estrace:

Estrace (16,703 reports)

Cardiac disorder treatments and more:

Cardiac disorder (160,332 reports)

Browse all side effects of Estrace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cardiac disorder:

Cardiac disorder (2,042 drugs)

Browse all the conditions that are associated with Cardiac disorder:

Cardiac disorder (1,960 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrace) and Estrace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.