Estradiol and Application site rash - a phase IV clinical study of FDA data

Summary:

Application site rash is reported as a side effect among people who take Estradiol (estradiol), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Oxytrol For Women, and have Menopausal symptoms.

The phase IV clinical study analyzes which people have Application site rash when taking Estradiol. It is created by eHealthMe based on reports of 17,352 people who have side effects when taking Estradiol from the FDA, and is updated regularly.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

What is Application site rash?

Application site rash is found to be associated with 397 drugs and 629 conditions by eHealthMe. Check the latest studies of Application site rash.

On Jul, 12, 2026

17,352 people reported to have side effects when taking Estradiol.
Among them, 73 people (0.42%) have Application site rash.

Could Estradiol cause Application site rash?

Among these 73 people:

How long have people been on Estradiol when they have Application site rash? *

What is the gender of people who have Application site rash when taking Estradiol? *

female: 97.06 %
male: 2.94 %

What is the age of people who have Application site rash when taking Estradiol? *

What are other drugs people take besides Estradiol? *

What are other side effects people have besides Application site rash? *

Application Site Pruritus (application site severe itching of the skin): 25 people, 34.25%
Application Site Erythema (redness of the skin at application site): 19 people, 26.03%
Application Site Irritation: 12 people, 16.44%
Headache (pain in head): 6 people, 8.22%
Hot Flush (sudden feelings of heat): 5 people, 6.85%
Rashes (redness): 5 people, 6.85%
Application Site Vesicles (small bubble within a cell at application site): 4 people, 5.48%
Application Site Pain: 4 people, 5.48%
Drug Ineffective: 3 people, 4.11%
Itching: 3 people, 4.11%

What are the existing conditions these people have? *

Menopausal Symptoms: 7 people, 9.59%
Hot Flush (sudden feelings of heat): 5 people, 6.85%
Premature Menopause: 4 people, 5.48%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 4.11%
High Blood Pressure: 2 people, 2.74%
Back Pain: 2 people, 2.74%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 2.74%
Pain: 2 people, 2.74%
High Blood Cholesterol: 1 person, 1.37%
Hair Loss: 1 person, 1.37%

* Approximation only. Some reports may have incomplete information.

Do you take Estradiol and have Application site rash?

- Check whether Application site rash is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estradiol:

Estradiol (18,986 reports)

Browse all side effects of Estradiol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site rash:

Application site rash (397 drugs)

Browse all the conditions that are associated with Application site rash:

Application site rash (629 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estradiol) and Estradiol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.