Estradiol and Common peroneal nerve dysfunction - a phase IV clinical study of FDA data

Summary:

Common peroneal nerve dysfunction is reported as a side effect among people who take Estradiol (estradiol), especially for people who are female, 60+ old, also take Neurontin, and have Cataplexy.

The phase IV clinical study analyzes which people have Common peroneal nerve dysfunction when taking Estradiol. It is created by eHealthMe based on reports of 17,352 people who have side effects when taking Estradiol from the FDA, and is updated regularly.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

What is Common peroneal nerve dysfunction?

Common peroneal nerve dysfunction (dysfunction of nerve controlling movement and sensation to the lower leg, foot and toes) is found to be associated with 651 drugs and 1,131 conditions by eHealthMe. Check the latest studies of Common peroneal nerve dysfunction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

17,352 people reported to have side effects when taking Estradiol.
Among them, 14 people (0.08%) have Common peroneal nerve dysfunction.

Could Estradiol cause Common peroneal nerve dysfunction?

Among these 14 people:

What is the gender of people who have Common peroneal nerve dysfunction when taking Estradiol? *

female: 92.86 %
male: 7.14 %

What is the age of people who have Common peroneal nerve dysfunction when taking Estradiol? *

What are other drugs people take besides Estradiol? *

What are other side effects people have besides Common peroneal nerve dysfunction? *

Fatigue (feeling of tiredness): 7 people, 50.00%
Gait Disturbance: 7 people, 50.00%
Pain In Extremity: 7 people, 50.00%
High Blood Pressure: 7 people, 50.00%
Swelling: 6 people, 42.86%
Pain: 6 people, 42.86%
Weakness: 6 people, 42.86%
Dry Mouth: 5 people, 35.71%
Back Pain: 5 people, 35.71%
Head Injury: 5 people, 35.71%

What are the existing conditions these people have? *

Urine Analysis Abnormal: 4 people, 28.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 28.57%
Muscle Aches (muscle pain): 4 people, 28.57%
Lewis-Sumner Syndrome (a dysimmune multifocal demyelinating sensorimotor neuropathy): 4 people, 28.57%
Hypocitraturia (low amount of citrate in the urine, is an important risk factor for kidney stone formation): 4 people, 28.57%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 4 people, 28.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 28.57%
High Blood Cholesterol: 3 people, 21.43%
Drowsiness: 3 people, 21.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Estradiol and have Common peroneal nerve dysfunction?

- Check whether Common peroneal nerve dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estradiol:

Estradiol (18,986 reports)

Browse all side effects of Estradiol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Common peroneal nerve dysfunction:

Common peroneal nerve dysfunction (651 drugs)

Browse all the conditions that are associated with Common peroneal nerve dysfunction:

Common peroneal nerve dysfunction (1,131 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estradiol) and Estradiol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.