Estradiol and Decreased activity - a phase IV clinical study of FDA data

Summary:

Decreased activity is reported as a side effect among people who take Estradiol (estradiol), especially for people who are female, 60+ old, also take Truvada, and have Hiv infection.

The phase IV clinical study analyzes which people have Decreased activity when taking Estradiol. It is created by eHealthMe based on reports of 17,352 people who have side effects when taking Estradiol from the FDA, and is updated regularly.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

What is Decreased activity?

Decreased activity is found to be associated with 1,111 drugs and 1,330 conditions by eHealthMe. Check the latest studies of Decreased activity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

17,352 people reported to have side effects when taking Estradiol.
Among them, 14 people (0.08%) have Decreased activity.

Could Estradiol cause Decreased activity?

Among these 14 people:

What is the gender of people who have Decreased activity when taking Estradiol? *

female: 100 %
male: 0.0 %

What is the age of people who have Decreased activity when taking Estradiol? *

What are other drugs people take besides Estradiol? *

What are other side effects people have besides Decreased activity? *

Pain: 6 people, 42.86%
Stress And Anxiety: 6 people, 42.86%
Emotional Distress: 5 people, 35.71%
Quality Of Life Decreased: 5 people, 35.71%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 5 people, 35.71%
Fatigue (feeling of tiredness): 4 people, 28.57%
Depression: 4 people, 28.57%
Drowsiness: 3 people, 21.43%
Weakness: 3 people, 21.43%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 21.43%

What are the existing conditions these people have? *

Hiv Infection: 5 people, 35.71%
Vulval Cancer: 1 person, 7.14%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 7.14%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 1 person, 7.14%
Depression: 1 person, 7.14%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 7.14%
High Blood Cholesterol: 1 person, 7.14%
High Blood Pressure: 1 person, 7.14%
Insomnia (sleeplessness): 1 person, 7.14%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Estradiol and have Decreased activity?

- Check whether Decreased activity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estradiol:

Estradiol (18,986 reports)

Browse all side effects of Estradiol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Decreased activity:

Decreased activity (1,111 drugs)

Browse all the conditions that are associated with Decreased activity:

Decreased activity (1,330 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estradiol) and Estradiol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.