Estradiol and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Estradiol (estradiol), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Gabapentin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Estradiol. It is created by eHealthMe based on reports of 17,352 people who have side effects when taking Estradiol from the FDA, and is updated regularly.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,228 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 16, 2026

17,352 people reported to have side effects when taking Estradiol.
Among them, 34 people (0.2%) have Knee joint replacement.

Could Estradiol cause Knee joint replacement?

Among these 34 people:

How long have people been on Estradiol when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Estradiol? *

female: 100 %
male: 0.0 %

What is the age of people who have Knee joint replacement when taking Estradiol? *

What are other drugs people take besides Estradiol? *

What are other side effects people have besides Knee joint replacement? *

Fall: 5 people, 14.71%
Weight Increased: 5 people, 14.71%
Sinusitis (inflammation of sinus): 5 people, 14.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 11.76%
Nausea (feeling of having an urge to vomit): 4 people, 11.76%
Joint Pain: 4 people, 11.76%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 11.76%
Itching: 4 people, 11.76%
Dizziness: 4 people, 11.76%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 11.76%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 29.41%
High Blood Pressure: 5 people, 14.71%
Drowsiness: 4 people, 11.76%
Immunodeficiency Common Variable: 4 people, 11.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 11.76%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 11.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 8.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.82%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 8.82%
Indigestion: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Estradiol and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estradiol:

Estradiol (18,986 reports)

Browse all side effects of Estradiol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,228 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estradiol) and Estradiol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.