Estradiol and Vaginal bleeding - a phase IV clinical study of FDA data

Summary:

Vaginal bleeding is reported as a side effect among people who take Estradiol (estradiol), especially for people who are 60+ old, have been taking the drug for < 1 month also take Progesterone, and have Menopausal symptoms.

The phase IV clinical study analyzes which people have Vaginal bleeding when taking Estradiol. It is created by eHealthMe based on reports of 17,352 people who have side effects when taking Estradiol from the FDA, and is updated regularly.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

What is Vaginal bleeding?

Vaginal bleeding is found to be associated with 1,134 drugs and 1,527 conditions by eHealthMe. Check the latest studies of Vaginal bleeding.

On Jul, 06, 2026

17,352 people reported to have side effects when taking Estradiol.
Among them, 86 people (0.5%) have Vaginal bleeding.

Among these 86 people:

How long have people been on Estradiol when they have Vaginal bleeding? *

What is the age of people who have Vaginal bleeding when taking Estradiol? *

What are other drugs people take besides Estradiol? *

What are other side effects people have besides Vaginal bleeding? *

Breast Pain: 9 people, 10.47%
Back Pain: 8 people, 9.30%
Fatigue (feeling of tiredness): 8 people, 9.30%
Drug Ineffective: 8 people, 9.30%
Abdominal Distension: 7 people, 8.14%
Abdominal Pain: 7 people, 8.14%
Muscle Spasms (muscle contraction): 7 people, 8.14%
Diarrhea: 6 people, 6.98%
Vaginal Discharge: 6 people, 6.98%
Hot Flush (sudden feelings of heat): 6 people, 6.98%

What are the existing conditions these people have? *

Vulvovaginal Dryness: 6 people, 6.98%
Menopausal Symptoms: 6 people, 6.98%
Pain: 4 people, 4.65%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 3.49%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 3.49%
Insomnia (sleeplessness): 3 people, 3.49%
Joint Pain: 3 people, 3.49%
High Blood Pressure: 3 people, 3.49%
Atrophic Vulvovaginitis (inflammation of the vulva): 3 people, 3.49%
Bone Loss: 2 people, 2.33%

* Approximation only. Some reports may have incomplete information.

Do you take Estradiol and have Vaginal bleeding?

- Check whether Vaginal bleeding is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estradiol:

Estradiol (18,986 reports)

Vaginal bleeding treatments and more:

Vaginal bleeding (49,485 reports)

Browse all side effects of Estradiol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vaginal bleeding:

Vaginal bleeding (1,134 drugs)

Browse all the conditions that are associated with Vaginal bleeding:

Vaginal bleeding (1,527 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estradiol) and Estradiol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.