Estring and Acne - a phase IV clinical study of FDA data

Summary:

Acne is reported as a side effect among people who take Estring (estradiol), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Premarin, and have Burkitt lymphoma.

The phase IV clinical study analyzes which people have Acne when taking Estring. It is created by eHealthMe based on reports of 5,418 people who have side effects when taking Estring from the FDA, and is updated regularly.

What is Estring?

Estring has active ingredients of estradiol. eHealthMe is studying from 5,474 Estring users. Check the latest studies of Estring.

What is Acne?

Acne (skin problems that cause pimples) is found to be associated with 1,313 drugs and 2,349 conditions by eHealthMe. Check the latest studies of Acne.



On Jul, 09, 2026

5,418 people reported to have side effects when taking Estring.
Among them, 17 people (0.31%) have Acne.

Could Estring cause Acne?

Among these 17 people:

How long have people been on Estring when they have Acne? *

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Acne when taking Estring? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Acne when taking Estring? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 6.67 %
  • 40-49: 6.67 %
  • 50-59: 13.33 %
  • 60+: 73.33 %

What are other drugs people take besides Estring? *

  1. Premarin: 9 people, 52.94%
  2. Zolpidem: 2 people, 11.76%
  3. Biotin: 2 people, 11.76%
  4. Gralise: 2 people, 11.76%
  5. K-Tab: 2 people, 11.76%
  6. Epipen: 2 people, 11.76%
  7. Zoloft: 2 people, 11.76%
  8. Lunesta: 2 people, 11.76%
  9. Dexedrine: 2 people, 11.76%
  10. Cytomel: 2 people, 11.76%

What are other side effects people have besides Acne? *

  1. Vulvovaginal Dryness: 9 people, 52.94%
  2. Drug Ineffective: 7 people, 41.18%
  3. Urinary Tract Disorder: 7 people, 41.18%
  4. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 5 people, 29.41%
  5. Emotional Distress: 4 people, 23.53%
  6. Dizziness: 3 people, 17.65%
  7. Hair Loss: 3 people, 17.65%
  8. Abdominal Discomfort: 2 people, 11.76%
  9. Insomnia (sleeplessness): 2 people, 11.76%
  10. Neoplasm Malignant (cancer tumour): 2 people, 11.76%

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 11.76%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 11.76%
  3. Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 11.76%
  4. Vulvovaginal Dryness: 1 person, 5.88%
  5. Vaginal Bleeding: 1 person, 5.88%
  6. Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 5.88%
  7. Sexual Intercourse - Painful: 1 person, 5.88%
  8. Irritable Bowel Syndrome: 1 person, 5.88%
  9. Insomnia (sleeplessness): 1 person, 5.88%
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Estring and have Acne?

- Check whether Acne is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estring:

Acne treatments and more:

  • Acne (179,011 reports)

How severe was Acne and when was it recovered:

Expand to all the drugs that have ingredients of estradiol:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Estring:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acne:

  • Acne (1,313 drugs)

Browse all the conditions that are associated with Acne:

  • Acne (2,349 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estring) and Estring (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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