Estring and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Estring (estradiol), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Ambien, and have Breast cancer.

The phase IV clinical study analyzes which people have Sciatica when taking Estring. It is created by eHealthMe based on reports of 5,418 people who have side effects when taking Estring from the FDA, and is updated regularly.

What is Estring?

Estring has active ingredients of estradiol. eHealthMe is studying from 5,474 Estring users. Check the latest studies of Estring.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,143 drugs and 1,433 conditions by eHealthMe. Check the latest studies of Sciatica.

On Jun, 19, 2026

5,418 people reported to have side effects when taking Estring.
Among them, 18 people (0.33%) have Sciatica.

Among these 18 people:

How long have people been on Estring when they have Sciatica? *

What is the gender of people who have Sciatica when taking Estring? *

female: 100 %
male: 0.0 %

What is the age of people who have Sciatica when taking Estring? *

What are other drugs people take besides Estring? *

What are other side effects people have besides Sciatica? *

Pain In Extremity: 12 people, 66.67%
Memory Loss: 11 people, 61.11%
Bone Disorder: 11 people, 61.11%
Stress And Anxiety: 11 people, 61.11%
Gums - Swollen: 10 people, 55.56%
Micturition Urgency (urgency to pass the urine): 10 people, 55.56%
Decreased Interest: 10 people, 55.56%
Lumbar Spinal Stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 10 people, 55.56%
Leukocytosis (increased white blood cells): 10 people, 55.56%
Intervertebral Disc Protrusion (spinal disc protrusion): 10 people, 55.56%

What are the existing conditions these people have? *

Hot Flush (sudden feelings of heat): 10 people, 55.56%
Breast Cancer: 10 people, 55.56%
Vulvovaginal Dryness: 5 people, 27.78%
Atrophic Vulvovaginitis (inflammation of the vulva): 4 people, 22.22%
Vulvovaginal Discomfort: 1 person, 5.56%
Stress And Anxiety: 1 person, 5.56%
Sexual Intercourse - Painful: 1 person, 5.56%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 5.56%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.56%
Micturition Disorder (disease of passing urine): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Estring and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estring:

Estring (5,474 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

Browse all side effects of Estring:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,143 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,433 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estring) and Estring (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.